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Journal of Clinical Microbiology, May 1997, 1216-1223, Vol 35, No. 5
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5' end of the large-subunit (26S) ribosomal DNA gene

CP Kurtzman and CJ Robnett
National Center for Agricultural Utilization Research, United States Department of Agriculture, Peoria, Illinois 61604, USA. mpcpk@ncaurl.ncaur.gov

Clinically important species of Candida and related organisms were compared for extent of nucleotide divergence in the 5' end of the large- subunit (26S) ribosomal DNA (rDNA) gene. This rDNA region is sufficiently variable to allow reliable separation of all known clinically significant yeast species. Of the 204 described species examined, 21 appeared to be synonyms of previously described organisms. Phylogenetic relationships among the species are presented.


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