This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beall, B.
Right arrow Articles by Schwartz, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beall, B.
Right arrow Articles by Schwartz, B.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, May 1997, 1231-1235, Vol 35, No. 5
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Survey of emm gene sequences and T-antigen types from systemic Streptococcus pyogenes infection isolates collected in San Francisco, California; Atlanta, Georgia; and Connecticut in 1994 and 1995

B Beall, R Facklam, T Hoenes and B Schwartz
Childhood and Respiratory Diseases Branch, Centers for Diseases Control and Prevention, Atlanta, Georgia 30333, USA. beb0@ciddbd2.em.cdc.gov

The variable 5' emm (M-protein gene) sequences and T-antigen types were determined from 340 systemic group A streptococcal (GAS) isolates taken from hospitalized patients in San Francisco, Calif.; Atlanta, Ga.; and Connecticut in 1994 and 1995. Eighty percent of these isolates had emm sequences and T-antigen types in agreement with previously recorded M- and T-antigen associations. Most of the remaining strains either were T nontypeable (11%) or contained emm genes encoding M proteins for which T-antigen associations have not been made (6%). One newly encountered emm gene, designated ST2974, from each of 13 isolates had the T type 8/25/Imp19. Another new emm gene, ST2967, from 8 of 11 isolates was T nontypeable. Six other unique emm gene sequences from seven isolates were encountered. Sequencing of the variable region of the emm gene of GAS isolates (emm typing) is effective for surveying the sequence variability of the M virulence protein, and combined with T typing, emm typing is useful for monitoring GAS strain diversity.


This article has been cited by other articles:

  • Ahmad, Y., Gertz, R. E. Jr., Li, Z., Sakota, V., Broyles, L. N., Van Beneden, C., Facklam, R., Shewmaker, P. L., Reingold, A., Farley, M. M., Beall, B. W. (2009). Genetic Relationships Deduced from emm and Multilocus Sequence Typing of Invasive Streptococcus dysgalactiae subsp. equisimilis and S. canis Recovered from Isolates Collected in the United States. J. Clin. Microbiol. 47: 2046-2054 [Abstract] [Full Text]  
  • Lloyd, C., Balakrishnan, N., Menon, T. (2008). vir types of Streptococcus pyogenes in Chennai, South India. J Med Microbiol 57: 1176-1177 [Full Text]  
  • Tanaka, D., Isobe, J., Watahiki, M., Nagai, Y., Katsukawa, C., Kawahara, R., Endoh, M., Okuno, R., Kumagai, N., Matsumoto, M., Morikawa, Y., Ikebe, T., Watanabe, H., and the Working Group for Group A Streptococci in, (2008). Genetic Features of Clinical Isolates of Streptococcus dysgalactiae subsp. equisimilis Possessing Lancefield's Group A Antigen. J. Clin. Microbiol. 46: 1526-1529 [Abstract] [Full Text]  
  • Tanna, A., Emery, M., Dhami, C., Arnold, E., Efstratiou, A. (2006). Molecular characterization of clinical isolates of M non-typable group A streptococci from invasive disease cases.. J Med Microbiol 55: 1419-1423 [Abstract] [Full Text]  
  • Akesson, P., Moritz, L., Truedsson, M., Christensson, B., von Pawel-Rammingen, U. (2006). IdeS, a Highly Specific Immunoglobulin G (IgG)-Cleaving Enzyme from Streptococcus pyogenes, Is Inhibited by Specific IgG Antibodies Generated during Infection. Infect. Immun. 74: 497-503 [Abstract] [Full Text]  
  • Tewodros, W., Kronvall, G. (2005). M Protein Gene (emm Type) Analysis of Group A Beta-Hemolytic Streptococci from Ethiopia Reveals Unique Patterns. J. Clin. Microbiol. 43: 4369-4376 [Abstract] [Full Text]  
  • Ecker, D. J., Sampath, R., Blyn, L. B., Eshoo, M. W., Ivy, C., Ecker, J. A., Libby, B., Samant, V., Sannes-Lowery, K. A., Melton, R. E., Russell, K., Freed, N., Barrozo, C., Wu, J., Rudnick, K., Desai, A., Moradi, E., Knize, D. J., Robbins, D. W., Hannis, J. C., Harrell, P. M., Massire, C., Hall, T. A., Jiang, Y., Ranken, R., Drader, J. J., White, N., McNeil, J. A., Crooke, S. T., Hofstadler, S. A. (2005). Rapid identification and strain-typing of respiratory pathogens for epidemic surveillance. Proc. Natl. Acad. Sci. USA 102: 8012-8017 [Abstract] [Full Text]  
  • Alberti, S., Garcia-Rey, C., Garcia-Laorden, M. I., Dal-Re, R., Garcia-de-Lomas, J., the Spanish Surveillance Group for Respiratory Pat, (2005). Survey of emm-Like Gene Sequences from Pharyngeal Isolates of Group C and Group G Streptococci Collected in Spain. J. Clin. Microbiol. 43: 1433-1436 [Abstract] [Full Text]  
  • Doktor, S. Z., Beyer, J. M., Flamm, R. K., Shortridge, V. D. (2005). Comparison of emm Typing and Ribotyping with Three Restriction Enzymes To Characterize Clinical Isolates of Streptococcus pyogenes. J. Clin. Microbiol. 43: 150-155 [Abstract] [Full Text]  
  • Vlaminckx, B. J. M., Mascini, E. M., Schellekens, J., Schouls, L. M., Paauw, A., Fluit, A. C., Novak, R., Verhoef, J., Schmitz, F. J. (2003). Site-Specific Manifestations of Invasive Group A Streptococcal Disease: Type Distribution and Corresponding Patterns of Virulence Determinants. J. Clin. Microbiol. 41: 4941-4949 [Abstract] [Full Text]  
  • Carlsson, F., Berggard, K., Stalhammar-Carlemalm, M., Lindahl, G. (2003). Evasion of Phagocytosis through Cooperation between Two Ligand-binding Regions in Streptococcus pyogenes M Protein. JEM 198: 1057-1068 [Abstract] [Full Text]  
  • Moses, A. E., Hidalgo-Grass, C., Dan-Goor, M., Jaffe, J., Shetzigovsky, I., Ravins, M., Korenman, Z., Cohen-Poradosu, R., Nir-Paz, R. (2003). emm Typing of M Nontypeable Invasive Group A Streptococcal Isolates in Israel. J. Clin. Microbiol. 41: 4655-4659 [Abstract] [Full Text]  
  • Yan, J.-J., Liu, C.-C., Ko, W.-C., Hsu, S.-Y., Wu, H.-M., Lin, Y.-S., Lin, M. T., Chuang, W.-J., Wu, J.-J. (2003). Molecular Analysis of Group A Streptococcal Isolates Associated with Scarlet Fever in Southern Taiwan between 1993 and 2002. J. Clin. Microbiol. 41: 4858-4861 [Abstract] [Full Text]  
  • Alberti, S., Garcia-Rey, C., Dominguez, M. A., Aguilar, L., Cercenado, E., Gobernado, M., Garcia-Perea,, A. (2003). Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility. J. Clin. Microbiol. 41: 2385-2390 [Abstract] [Full Text]  
  • Ho, P. L., Johnson, D. R., Yue, A. W. Y., Tsang, D. N. C., Que, T. L., Beall, B., Kaplan, E. L. (2003). Epidemiologic Analysis of Invasive and Noninvasive Group A Streptococcal Isolates in Hong Kong. J. Clin. Microbiol. 41: 937-942 [Abstract] [Full Text]  
  • Lei, B., DeLeo, F. R., Reid, S. D., Voyich, J. M., Magoun, L., Liu, M., Braughton, K. R., Ricklefs, S., Hoe, N. P., Cole, R. L., Leong, J. M., Musser, J. M. (2002). Opsonophagocytosis-Inhibiting Mac Protein of Group A Streptococcus: Identification and Characteristics of Two Genetic Complexes. Infect. Immun. 70: 6880-6890 [Abstract] [Full Text]  
  • Smoot, L. M., McCormick, J. K., Smoot, J. C., Hoe, N. P., Strickland, I., Cole, R. L., Barbian, K. D., Earhart, C. A., Ohlendorf, D. H., Veasy, L. G., Hill, H. R., Leung, D. Y. M., Schlievert, P. M., Musser, J. M. (2002). Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks. Infect. Immun. 70: 7095-7104 [Abstract] [Full Text]  
  • Tyrrell, G. J., Lovgren, M., Forwick, B., Hoe, N. P., Musser, J. M., Talbot, J. A. (2002). M Types of Group A Streptococcal Isolates Submitted to the National Centre for Streptococcus (Canada) from 1993 to 1999. J. Clin. Microbiol. 40: 4466-4471 [Abstract] [Full Text]  
  • Beres, S. B., Sylva, G. L., Barbian, K. D., Lei, B., Hoff, J. S., Mammarella, N. D., Liu, M.-Y., Smoot, J. C., Porcella, S. F., Parkins, L. D., Campbell, D. S., Smith, T. M., McCormick, J. K., Leung, D. Y. M., Schlievert, P. M., Musser, J. M. (2002). Genome sequence of a serotype M3 strain of group A Streptococcus: Phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc. Natl. Acad. Sci. USA 99: 10078-10083 [Abstract] [Full Text]  
  • Hu, M. C., Walls, M. A., Stroop, S. D., Reddish, M. A., Beall, B., Dale, J. B. (2002). Immunogenicity of a 26-Valent Group A Streptococcal Vaccine. Infect. Immun. 70: 2171-2177 [Abstract] [Full Text]  
  • Nallapareddy, S. R., Duh, R.-W., Singh, K. V., Murray, B. E. (2002). Molecular Typing of Selected Enterococcus faecalis Isolates: Pilot Study Using Multilocus Sequence Typing and Pulsed-Field Gel Electrophoresis. J. Clin. Microbiol. 40: 868-876 [Abstract] [Full Text]  
  • Teixeira, L. M., Barros, R. R., Castro, A. C. D., Peralta, J. M., Da Gloria S. Carvalho, M., Talkington, D. F., Vivoni, A. M., Facklam, R. R., Beall, B. (2001). Genetic and Phenotypic Features of Streptococcus pyogenes Strains Isolated in Brazil That Harbor New emm Sequences. J. Clin. Microbiol. 39: 3290-3295 [Abstract] [Full Text]  
  • Reid, S. D., Green, N. M., Buss, J. K., Lei, B., Musser, J. M. (2001). Multilocus analysis of extracellular putative virulence proteins made by group A Streptococcus: Population genetics, human serologic response, and gene transcription. Proc. Natl. Acad. Sci. USA 98: 7552-7557 [Abstract] [Full Text]  
  • Enright, M. C., Spratt, B. G., Kalia, A., Cross, J. H., Bessen, D. E. (2001). Multilocus Sequence Typing of Streptococcus pyogenes and the Relationships between emm Type and Clone. Infect. Immun. 69: 2416-2427 [Abstract] [Full Text]  
  • Cunningham, M. W. (2000). Pathogenesis of Group A Streptococcal Infections. Clin. Microbiol. Rev. 13: 470-511 [Abstract] [Full Text]  
  • Beall, B., Gherardi, G., Lovgren, M., Facklam, R. R., Forwick, B. A., Tyrrell, G. J. (2000). emm and sof gene sequence variation in relation to serological typing of opacity-factor-positive group A streptococci. Microbiology 146: 1195-1209 [Abstract] [Full Text]  
  • PHILLIPS, G., EFSTRATIOU, A., TANNA, A., BEALL, B., FERGUSON, J., ROWORTH, M. (2000). An outbreak of skin sepsis in abattoir workers caused by an 'unusual' strain of Streptococcus pyogenes. J Med Microbiol 49: 371-374 [Abstract] [Full Text]  
  • Lukomski, S., Hoe, N. P., Abdi, I., Rurangirwa, J., Kordari, P., Liu, M., Dou, S.-J., Adams, G. G., Musser, J. M. (2000). Nonpolar Inactivation of the Hypervariable Streptococcal Inhibitor of Complement Gene (sic) in Serotype M1 Streptococcus pyogenes Significantly Decreases Mouse Mucosal Colonization. Infect. Immun. 68: 535-542 [Abstract] [Full Text]  
  • York, M. K., Gibbs, L., Perdreau-Remington, F., Brooks, G. F. (1999). Characterization of Antimicrobial Resistance in Streptococcus pyogenes Isolates from the San Francisco Bay Area of Northern California. J. Clin. Microbiol. 37: 1727-1731 [Abstract] [Full Text]  
  • Stockbauer, K. E., Magoun, L., Liu, M., Burns, E. H. Jr., Gubba, S., Renish, S., Pan, X., Bodary, S. C., Baker, E., Coburn, J., Leong, J. M., Musser, J. M. (1999). A natural variant of the cysteine protease virulence factor of group A Streptococcus with an arginine-glycine-aspartic acid (RGD) motif preferentially binds human integrins alpha vbeta 3 and alpha IIbbeta 3. Proc. Natl. Acad. Sci. USA 96: 242-247 [Abstract] [Full Text]  
  • Cleary, P. P., LaPenta, D., Vessela, R., Lam, H., Cue, D. (1998). A Globally Disseminated M1 Subclone of Group A Streptococci Differs from Other Subclones by 70 Kilobases of Prophage DNA and Capacity for High-Frequency Intracellular Invasion. Infect. Immun. 66: 5592-5597 [Abstract] [Full Text]  
  • Johnsson, E., Berggard, K., Kotarsky, H., Hellwage, J., Zipfel, P. F., Sjobring, U., Lindahl, G. (1998). Role of the Hypervariable Region in Streptococcal M Proteins: Binding of a Human Complement Inhibitor. J. Immunol. 161: 4894-4901 [Abstract] [Full Text]  
  • Gardiner, D. L., Goodfellow, A. M., Martin, D. R., Sriprakash, K. S. (1998). Group A Streptococcal Vir Types Are M-Protein Gene (emm) Sequence Type Specific. J. Clin. Microbiol. 36: 902-907 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»