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Journal of Clinical Microbiology, Jul 1997, 1766-1768, Vol 35, No. 7
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Differentiation of primary from nonprimary genital herpes infections by a herpes simplex virus-specific immunoglobulin G avidity assay

M Hashido, S Inouye and T Kawana
Department of Epidemiology, National Institute of Health, Shinjuku-ku, Tokyo, Japan.

An immunoglobulin G (IgG) antibody avidity assay which uses protein- denaturing agents and a modification of an enzyme-linked immunosorbent assay have been investigated for their usefulness in distinguishing primary genital herpes simplex virus (HSV) infections from nonprimary infections. Forty-nine serum specimens from patients with primary, recurrent, and nonprimary first-episode genital herpes were studied. The clearest separation was obtained with 6 M urea treatment, giving mean avidity indices of 0.398 for sera < or = 100 days after the infection and 0.879 for sera > 100 days after the infection (P < 0.001). No significant difference in avidity indices was observed between the recurrent and nonprimary first-episode infections. Determination of the avidity of HSV-specific IgG will improve the diagnostic potential of HSV serology.


This article has been cited by other articles:

  • Umene, K., Kawana, T. (2003). Divergence of reiterated sequences in a series of genital isolates of herpes simplex virus type 1 from individual patients. J. Gen. Virol. 84: 917-923 [Abstract] [Full Text]  
  • Revello, M. G., Gerna, G. (2002). Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant. Clin. Microbiol. Rev. 15: 680-715 [Abstract] [Full Text]  


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