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Journal of Clinical Microbiology, January 1998, p. 281-283, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Long-Term Predictive Value of a Single Cytomegalovirus (CMV) DNA PCR Assay for CMV Disease in Human Immunodeficiency Virus-Infected Patients

Sharon Walmsley,* Tony Mazzulli, and Mel Krajden

Departments of Medicine and Clinical Biochemistry, The Toronto Hospital, Mount Sinai Hospital, and the University of Toronto, Toronto, Ontario, Canada

Received 23 June 1997/Returned for modification 26 August 1997/Accepted 21 October 1997

Universal prophylaxis with oral ganciclovir is not cost-effective for the prevention of cytomegalovirus (CMV) disease in human immunodeficiency virus infection. For a preemptive strategy to be considered, patients at highest risk for CMV disease need to be easily and accurately identified. In this study, the sensitivity, specificity, positive predictive value, and negative predictive value of a single CMV DNA PCR assay for the subsequent development of CMV disease were 0.75, 0.89, 0.75, and 0.89, respectively.

* Corresponding author. Mailing address: The Toronto Hospital, Eaton Wing, Ground Floor, Room 219, 200 Elizabeth St., Toronto, Ontario, Canada M5G 2C4. Phone: (416) 340-3871. Fax: (416) 595-5826. E-mail: swalmsley{at}torhosp.toronto.on.ca.

Journal of Clinical Microbiology, January 1998, p. 281-283, Vol. 36, No. 1
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pellegrin, I., Garrigue, I., Binquet, C., Chene, G., Neau, D., Bonot, P., Bonnet, F., Fleury, H., Pellegrin, J.-L. (1999). Evaluation of New Quantitative Assays for Diagnosis and Monitoring of Cytomegalovirus Disease in Human Immunodeficiency Virus-Positive Patients. J. Clin. Microbiol. 37: 3124-3132 [Abstract] [Full Text]  


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