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Journal of Clinical Microbiology, October 1998, p. 3066-3069, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Confirmation of Nosocomial Transmission of Hepatitis C Virus by Phylogenetic Analysis of the NS5-B Region

Heléne Norder,1,* Åsa Bergström,1 Ingrid Uhnoo,2 Jöran Aldén,3 Lars Weiss,4 Jan Czajkowski,5 and Lars Magnius1

Swedish Institute for Infectious Disease Control, Stockholm,1 Department of Infectious Diseases, Uppsala University Hospital, Uppsala,2 Department of Infectious Disease Control, Falun Hospital, Falun,3 and Dialysis Unit, Department of Medicine,4 and Serology Unit, Microbiological Laboratory,5 Central Hospital, Karlstad, Sweden

Received 10 November 1997/Returned for modification 9 February 1998/Accepted 6 July 1998

Four hepatitis C virus transmission chains at three dialysis units were disclosed by limited sequencing; three of these were disclosed by analysis of the NS5-B region of the genome. Dialysis on the same shift as that during which infected patients were dialyzed was the common factor for seven patients in two chains. Two nurses exposed to needle sticks and their sources of infection constituted two other chains. The strains of three chains belonged to subtype 1a and formed clusters with an intrachain variability of 0 to 6 nucleotides compared to 8 to 37 nucleotides for unrelated strains within this subtype. The clusters were supported by bootstrap values ranging from 89 to 100%.

* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden. Phone: 46 (8) 735 13 00. Fax: 46 (8) 730-32 48. E-mail: helene.norder{at}smi.ki.se.

Journal of Clinical Microbiology, October 1998, p. 3066-3069, Vol. 36, No. 10
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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