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Journal of Clinical Microbiology, November 1998, p. 3188-3192, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Inducible beta -Lactam Resistance in Aeromonas hydrophila: Therapeutic Challenge for Antimicrobial Therapy

Wen-Chien Ko,1,2 Hsiu-Mei Wu,3 Tsung-Chain Chang,3 Jing-Jou Yan,4 and Jiunn-Jong Wu3,*

Departments of Internal Medicine1 and Pathology,4 National Cheng Kung University Hospital, and Departments of Medicine2 and Medical Technology,3 National Cheng Kung University Medical College, Tainan, Taiwan

Received 3 March 1998/Returned for modification 20 April 1998/Accepted 3 August 1998

Despite the abundant amount of knowledge about inducible chromosomally mediated beta -lactamases among Aeromonas species, extended-spectrum beta -lactam-resistant A. hydrophila strains selected in clinical practice were rarely reported. In the present study, two strains of A. hydrophila, A136 and A139, with markedly different susceptibilities to extended-spectrum cephalosporins were isolated from blood and the tip segment of an arterial catheter of a burn patient. Another strain (A136m) was selected in vitro by culturing A136 in a subinhibitory concentration of cefotaxime, the beta -lactam agent administered for the treatment of Aeromonas bacteremia in this patient. Typing studies by arbitrarily primed PCR and pulsed-field gel electrophoresis indicated a clonal relationship among strains A136, A136m, and A139. These strains were identified to be of DNA hybridization group 1. Wild-type strain A136 was resistant only to ampicillin and cephamycins, but A136m and A139 were highly resistant to the expanded- and broad-spectrum cephalosporins. The presence of increased beta -lactamase activity in A139 suggests that A139 is a derepressed mutant which overexpresses beta -lactamases. These results call attention to the use of beta -lactam agents for the treatment of invasive Aeromonas infections.

* Corresponding author. Mailing address: Department of Medical Technology, National Cheng Kung University Medical College, No. 1 University Rd., Tainan, Taiwan. Phone: 886-6-2353535, ext. 5775. Fax: 886-6-2363956. E-mail: jjWu{at}mail.ncku.edu.tw.

Journal of Clinical Microbiology, November 1998, p. 3188-3192, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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