This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mbayed, V. A.
Right arrow Articles by Campos, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mbayed, V. A.
Right arrow Articles by Campos, R.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, November 1998, p. 3362-3365, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Distribution of Hepatitis B Virus Genotypes in Two Different Pediatric Populations from Argentina

V. A. Mbayed,1 J. L. López,1 P. F. S. Telenta,1 G. Palacios,1 I. Badía,2 A. Ferro,2 C. Galoppo,2 and R. Campos1,*

Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires,1 and Hospital de Niños Ricardo Gutiérrez,2 Buenos Aires, Argentina

Received 6 April 1998/Returned for modification 22 June 1998/Accepted 19 August 1998

Differences in pathogenesis and the probability of becoming a chronic carrier depend on the age at which hepatitis B virus (HBV) infection is acquired, ranging from 82% in infants less than 6 months of age to 15 to 30% in older children. HBV genotypes from 22 pediatric patients from two areas that differ in prevalence have been determined. Phylogenetic analysis shows a clear difference between the genotype distribution in Buenos Aires, a low-prevalence area, and that found in Gualeguay, Entre Ríos, a high-prevalence area. While the analysis allocated the sequences in the Buenos Aires group to genotypes A (36%), D (9%), and F (55%), the Gualeguay group presented exclusively genotype A isolates with very low nucleotide divergence, which suggests a strong founder viral population. The high prevalence of genotype F in the Buenos Aires group and its high intragroup heterogeneity agree with the American origin of this genotype.

* Corresponding author. Mailing address: Cátedra de Virología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 956, 4 piso (1113), Buenos Aires, Argentina. Phone: 54-1-9648264. Fax: 54-1-5083645. E-mail: rcampos{at}ffyb.uba.ar.

Journal of Clinical Microbiology, November 1998, p. 3362-3365, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mathet, V. L., Cuestas, M. L., Ruiz, V., Minassian, M. L., Rivero, C., Trinks, J., Daleoso, G., Leon, L. M., Sala, A., Libellara, B., Corach, D., Oubina, J. R. (2006). Detection of Hepatitis B Virus (HBV) Genotype E Carried--Even in the Presence of High Titers of Anti-HBs Antibodies--by an Argentinean Patient of African Descent Who Had Received Vaccination against HBV.. J. Clin. Microbiol. 44: 3435-3439 [Abstract] [Full Text]  
  • Franca, P. H. C., Gonzalez, J. E., Munne, M. S., Brandao, L. H., Gouvea, V. S., Sablon, E., Vanderborght, B. O. M. (2004). Strong Association between Genotype F and Hepatitis B Virus (HBV) e Antigen-Negative Variants among HBV-Infected Argentinean Blood Donors. J. Clin. Microbiol. 42: 5015-5021 [Abstract] [Full Text]  
  • Arauz-Ruiz, P., Norder, H., Robertson, B. H., Magnius, L. O. (2002). Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J. Gen. Virol. 83: 2059-2073 [Abstract] [Full Text]  
  • Kidd-Ljunggren, K., Miyakawa, Y., Kidd, A. H. (2002). Genetic variability in hepatitis B viruses. J. Gen. Virol. 83: 1267-1280 [Abstract] [Full Text]  
  • Paulij, W. P., de Wit, P. L. M., Sünnen, C. M. G., van Roosmalen, M. H., Petersen-van Ettekoven, A., Cooreman, M. P., Heijtink, R. A. (1999). Localization of a unique hepatitis B virus epitope sheds new light on the structure of hepatitis B virus surface antigen. J. Gen. Virol. 80: 2121-2126 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»