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Journal of Clinical Microbiology, November 1998, p. 3415-3416, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Ampicillin-Sulbactam and Amoxicillin-Clavulanic Acid against Acinetobacter baumannii

Anita Pandey, Arti Kapil,* Seema Sood, Vikas Goel, Bimal Das, and Pradeep Seth

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India 110029

Received 2 February 1998/Returned for modification 24 March 1998/Accepted 9 July 1998

In vitro susceptibility patterns of newer beta -lactamase-inhibiting antibiotics ampicillin-sulbactam (A/S) and amoxicillin-clavulanic acid (A/C) for 100 consecutive isolates of Acinetobacter baumannii obtained from various clinical samples were studied. The A/C MIC for 86% of the strains was more than 16/8 µg/ml, whereas there was an A/S MIC of more than 16/8 µg/ml for only 38% of the strains. This showed that A/S has significantly superior in vitro activity compared to A/C against A. baumannii, although, theoretically, both should have similar activities. The therapeutic superiority of A/S over A/C needs to be studied, or else the breakpoints for these agents in in vitro tests need to be redefined.

* Corresponding author. Mailing address: Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India 110029. Phone: 91-011-619-5105. Fax: 91-011-686-2663. E-mail: akapil{at}medinst.ernet.in.

Journal of Clinical Microbiology, November 1998, p. 3415-3416, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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