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Journal of Clinical Microbiology, November 1998, p. 3435-3437, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Helicobacter pylori cagA Status and s and m Alleles of vacA in Isolates from Individuals with a Variety of H. pylori-Associated Gastric Diseases

Dolores G. Evans,1,* Dulciene M. M. Queiroz,2 Edilberto N. Mendes,2 and Doyle J. Evans Jr.1

Department of Medicine, Baylor College of Medicine, and Bacterial Enteropathogens Laboratory, Gastroenterology Section, Veterans Affairs Medical Center, Houston, Texas 77030,1 and Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil2

Received 17 April 1998/Returned for modification 30 June 1998/Accepted 19 August 1998

The cagA gene was detected in 100% of 16 Helicobacter pylori isolates from patients with gastric carcinoma versus 78% of 18 isolates from patients with duodenal ulcers (P = 0.344) and only 64% of 22 isolates from patients with gastritis only (P = 0.005) in Brazil. Also, there was a significant association between isolation of cagA+ s1-type vacA H. pylori in cases of stomach cancer and ulcers as opposed to cases of gastritis only (P = 0.004), but this was not true in Houston (P = 0.238), where 94% of all isolates were cagA+.

* Corresponding author. Mailing address: Gastroenterology (111D), V.A. Medical Center, 2002 Holcombe Blvd., Houston, TX 77030. Phone: (713) 791-1414, ext. 4828. Fax: (713) 794-7750. E-mail: devans{at}bcm.tmc.edu.

Journal of Clinical Microbiology, November 1998, p. 3435-3437, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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