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Journal of Clinical Microbiology, November 1998, p. 3441-3442, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of Two Rapid Whole-Blood Tests for Helicobacter pylori Infection in Chinese Patients

Wai Keung Leung,1 Francis K. L. Chan,1,* Matthew S. Falk,1 Roamy Suen,2 and Joseph J. Y. Sung1

Departments of Medicine and Therapeutics1 and Surgery,2 Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong

Received 15 May 1998/Returned for modification 10 July 1998/Accepted 2 August 1998

Consecutive Chinese patients undergoing endoscopy for dyspepsia were tested for Helicobacter pylori infection by two rapid whole-blood tests: FlexPack HP (Abbott Laboratories) and Helisal One-Step (Cortecs Diagnostics). Biopsy-based tests (rapid urease test and histology) and the [13C]urea breath test were used as the "gold standard." One hundred sixty-one consecutive patients were studied, and 88 (54.7%) were confirmed to have H. pylori infection. The sensitivities, specificities, and positive and negative predictive values were 81.8%, 83.6% (P = 0.008), 85.7% (P = 0.04), and 79.2% for FlexPack HP and 84.1%, 63.0% (P = 0.008), 73.3% (P = 0.047), and 76.7% for Helisal One-Step, respectively.

* Corresponding author. Mailing address: Department of Medicine & Therapeutics, Chinese University of Hong Kong, Shatin, Hong Kong. Phone: (852) 2632 3146. Fax: (852) 2637 3852. E-mail: fklchan{at}cuhk.edu.hk.

Journal of Clinical Microbiology, November 1998, p. 3441-3442, Vol. 36, No. 11
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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