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Journal of Clinical Microbiology, March 1998, p. 792-795, Vol. 36, No. 3
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Nosocomial Cluster of Candida inconspicua Infections in Patients with Hematological Malignancies

Domenico D'Antonio,1,2,* Beatrice Violante,1,2 Aldo Mazzoni,3 Tiziana Bonfini,2 M. Assunta Capuani,4 Francesco D'Aloia,4 Antonio Iacone,1,2 Francesco Schioppa,4 and Ferdinando Romano4

Servizio di Microbiologia Clinica del Dipartimento di Ematologia ed Oncologia, Ospedale Santo Spirito, Pescara,1 Cattedra di Ematologia2 and Sezione di Epidemiologia e Sanità Pubblica, Dipartimento di Scienze Biomediche,4 Università G. D'Annunzio, Chieti, and Istituto di Microbiologia, Università di Bologna, Bologna,3 Italy

Received 4 August 1997/Returned for modification 22 September 1997/Accepted 25 November 1997

Candida inconspicua was recovered from three patients with hematological malignancies. Two patients had intravenous-catheter-associated fungemia, whereas the third had fungal hepatitis. The three cases of infection occurred over a period of 1 month in patients staying in adjacent single rooms. In vitro susceptibility testing of fungal strains showed all isolates to be resistant to fluconazole, with MICs greater than 32 µg/ml. All of the strains had identical DNA restriction profiles and randomly amplified polymorphic DNA fingerprints. These data suggest a nosocomially acquired infection emanating from a common source within the hospital environment.

* Corresponding author. Mailing address: Dipartimento di Ematologia ed Oncologia, Ospedale Santo Spirito di Pescara, Via Fonte Romana, 65100 Pescara, Italy. Phone: 39-85-4252687. Fax: 39-85-4252607.

Journal of Clinical Microbiology, March 1998, p. 792-795, Vol. 36, No. 3
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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