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Journal of Clinical Microbiology, April 1998, p. 1137-1138, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Detection of JC Virus in Cerebrospinal Fluid (CSF) Samples from Patients with Progressive Multifocal Leukoencephalopathy but Not in CSF Samples from Patients with Herpes Simplex Encephalitis, Enteroviral Meningitis, or Multiple Sclerosis

G. Bogdanovic,1 P. Priftakis,1 A.-L. Hammarin,2 M. Söderström,3 A. Samuelson,1 I. Lewensohn-Fuchs,1 and T. Dalianis1,*

Division of Clinical Virology, Department of Immunology, Microbiology, Pathology, and Infectious Diseases,1 and Department of Ophthalmology and Neurology,3 Karolinska Institute, Huddinge University Hospital, Huddinge, and Department of Virology, Swedish Institute for Infectious Disease Control, Stockholm,2 Sweden

Received 15 October 1997/Returned for modification 17 December 1997/Accepted 5 January 1998

JC virus (JCV) DNA was detected in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy (PML) but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. This suggests that inflammatory processes in the brain do not necessarily reactivate JCV, which further supports the proposal that the presence of JCV DNA in the CSF is diagnostic for PML.

* Corresponding author. Mailing address: Division of Clinical Virology F68, Karolinska Institute, Huddinge University Hospital, 141 86 Huddinge, Sweden. Phone: 46 8 58581382. Fax: 46 8 58587933. E-mail: Tina.Dalianis{at}impi.ki.se.

Journal of Clinical Microbiology, April 1998, p. 1137-1138, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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