This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mastrantonio, P.
Right arrow Articles by Tozzi, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mastrantonio, P.
Right arrow Articles by Tozzi, A. E.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 1998, p. 999-1002, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Bordetella parapertussis Infection in Children: Epidemiology, Clinical Symptoms, and Molecular Characteristics of Isolates

Paola Mastrantonio,1,* P. Stefanelli,1 M. Giuliano,1 Y. Herrera Rojas,1 M. Ciofi degli Atti,2 A. Anemona,2 and A. E. Tozzi2

Department of Bacteriology and Medical Mycology1 and Department of Epidemiology,2 Istituto Superiore di Sanità, Rome, Italy

Received 29 September 1997/Returned for modification 17 November 1997/Accepted 26 December 1997

The clinical trial conducted in Italy to evaluate the efficacy of acellular pertussis vaccines provided an opportunity to estimate the frequency of clinical infections with Bordetella parapertussis and to compare the clinical characteristics of children suffering from Bordetella pertussis illness with those of children with B. parapertussis illness. This study dealt with 76 B. parapertussis infections diagnosed from a population of 15,601 children participating in the follow-up of suspected cases of pertussis. An overall incidence of 2.1 cases of laboratory-confirmed parapertussis per 1,000 person-years was observed. Children affected by B. parapertussis infections showed a less severe clinical picture both in the duration of symptoms and in the percentage of patients affected, even when compared with vaccinated children with pertussis. To characterize the isolated strains, we performed assays for susceptibility to erythromycin and sulfamethoxazole-trimethoprim, and we examined the genomic DNAs by pulsed-field gel electrophoresis. The results showed a high degree of genetic stability among B. parapertussis strains regardless of time of collection and geographical distribution.

* Corresponding author. Mailing address: Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 0039 6 49902335. Fax: 0039 6 49387112. E-mail: pmastran{at}net.iss.it.

Journal of Clinical Microbiology, April 1998, p. 999-1002, Vol. 36, No. 4
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Zhang, X., Goebel, E. M., Rodriguez, M. E., Preston, A., Harvill, E. T. (2009). The O Antigen Is a Critical Antigen for the Development of a Protective Immune Response to Bordetella parapertussis. Infect. Immun. 77: 5050-5058 [Abstract] [Full Text]  
  • Fedele, G., Nasso, M., Spensieri, F., Palazzo, R., Frasca, L., Watanabe, M., Ausiello, C. M. (2008). Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis Differently Modulate Human Dendritic Cell Functions Resulting in Divergent Prevalence of Th17-Polarized Responses. J. Immunol. 181: 208-216 [Abstract] [Full Text]  
  • Goebel, E. M., Wolfe, D. N., Elder, K., Stibitz, S., Harvill, E. T. (2008). O Antigen Protects Bordetella parapertussis from Complement. Infect. Immun. 76: 1774-1780 [Abstract] [Full Text]  
  • Wolfe, D. N., Goebel, E. M., Bjornstad, O. N., Restif, O., Harvill, E. T. (2007). The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity. Infect. Immun. 75: 4972-4979 [Abstract] [Full Text]  
  • Wolfe, D. N., Kirimanjeswara, G. S., Goebel, E. M., Harvill, E. T. (2007). Comparative Role of Immunoglobulin A in Protective Immunity against the Bordetellae. Infect. Immun. 75: 4416-4422 [Abstract] [Full Text]  
  • Wolfe, D. N., Kirimanjeswara, G. S., Harvill, E. T. (2005). Clearance of Bordetella parapertussis from the Lower Respiratory Tract Requires Humoral and Cellular Immunity. Infect. Immun. 73: 6508-6513 [Abstract] [Full Text]  
  • Mattoo, S., Cherry, J. D. (2005). Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies. Clin. Microbiol. Rev. 18: 326-382 [Abstract] [Full Text]  
  • Gzyl, A., Augustynowicz, E., Mosiej, E., Zawadka, M., Gniadek, G., Nowaczek, A., Slusarczyk, J. (2005). Amplified fragment length polymorphism (AFLP) versus randomly amplified polymorphic DNA (RAPD) as new tools for inter- and intra-species differentiation within Bordetella. J Med Microbiol 54: 333-346 [Abstract] [Full Text]  
  • Makinen, J., Mertsola, J., Soini, H., Arvilommi, H., Viljanen, M. K., Guiso, N., He, Q. (2003). PFGE and pertactin gene sequencing suggest limited genetic variability within the Finnish Bordetella parapertussis population. J Med Microbiol 52: 1059-1063 [Abstract] [Full Text]  
  • Liese, J G, Renner, C, Stojanov, S, Belohradsky, B H, The Munich Vaccine Study Group, (2003). Clinical and epidemiological picture of B pertussis and B parapertussis infections after introduction of acellular pertussis vaccines. Arch. Dis. Child. 88: 684-687 [Abstract] [Full Text]  
  • Nygren, M., Reizenstein, E., Ronaghi, M., Lundeberg, J. (2000). Polymorphism in the Pertussis Toxin Promoter Region Affecting the DNA-Based Diagnosis of Bordetella Infection. J. Clin. Microbiol. 38: 55-60 [Abstract] [Full Text]  
  • Ausiello, C. M., Lande, R., Urbani, F., la Sala, A., Stefanelli, P., Salmaso, S., Mastrantonio, P., Cassone, A. (1999). Cell-Mediated Immune Responses in Four-Year-Old Children after Primary Immunization with Acellular Pertussis Vaccines. Infect. Immun. 67: 4064-4071 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»