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Journal of Clinical Microbiology, May 1998, p. 1366-1370, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Presence of Multiple "Helicobacter heilmannii" Strains in an Individual Suffering from Ulcers and in His Two Cats

Christine Dieterich,1 Paul Wiesel,1 Reto Neiger,2 André Blum,1 and Irène Corthésy-Theulaz1,*

Division of Gastroenterology, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne,1 and Inselspital, Bern,2 Switzerland

Received 15 September 1997/Returned for modification 19 December 1997/Accepted 18 February 1998

Circumstantial evidence suggests that "Helicobacter heilmannii" infection is an example of zoonosis. The presence of "H. heilmannii" strains in a human subject with acute gastric erosions, in his two cats, and in two unrelated cats was analyzed, and the genetic relatedness of the human and feline strains was assessed. A 580-bp, PCR-amplified sequence of "H. heilmannii" urease B gene (ureB) obtained from biopsies from the human subject and his two cats was restricted with AluI and cloned for sequencing. Analysis of the restriction fragment length polymorphism of the ureB-amplified product suggested the presence of different individual "H. heilmannii" strains in the cats and of three distinct strains in the human subject. One of the "H. heilmannii" ureB sequences amplified from the human subject's biopsies was identical to that derived from one of his cats. The degree of similarity between the other "H. heilmannii" human and feline nucleotide sequences was higher than 97%. Most of the base substitutions were conservative. We conclude that human and animal "H. heilmannii" strains are closely related and that humans can be infected by more than one "H. heilmannii" strain, as has been observed for Helicobacter pylori.

* Corresponding author. Mailing address: Division de Gastro-entérologie, Département de Médecine Interne, CHUV - BH-19N-624, CH-1011 Lausanne, Switzerland. Phone: 41 21 314 06 85. Fax: 41 21 314 06 84. E-mail: Irene.CorthesyTheulaz{at}ipharm.unil.ch.

Journal of Clinical Microbiology, May 1998, p. 1366-1370, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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