This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Girmenia, C.
Right arrow Articles by Martino, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Girmenia, C.
Right arrow Articles by Martino, P.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, May 1998, p. 1436-1438, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Use of Voriconazole in Treatment of Scedosporium apiospermum Infection: Case Report

Corrado Girmenia,* Giovanni Luzi, Monica Monaco, and Pietro Martino

Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Rome, Italy

Received 30 October 1997/Returned for modification 18 December 1997/Accepted 19 February 1998

We report a case of disseminated Scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. Due to progression of the mycosis after 7 days of amphotericin B lipid complex therapy and to high susceptibility of the mold to voriconazole in vitro, the patient was treated with intravenous voriconazole. After a few days of therapy, fever disappeared and skin lesions improved. However, the patient died after 1 month due to intestinal bleeding. Despite a negative outcome, this case seems to indicate a promising role for voriconazole in the treatment of S. apiospermum infections.

* Corresponding author. Mailing address: Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza," Via Benevento 6, 00161 Rome, Italy. Phone: 06/857951. Fax: 06/44241984. E-mail: GIRMENIA{at}BCE.MED.UNIROMA1.IT.

Journal of Clinical Microbiology, May 1998, p. 1436-1438, Vol. 36, No. 5
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Troke, P., Aguirrebengoa, K., Arteaga, C., Ellis, D., Heath, C. H., Lutsar, I., Rovira, M., Nguyen, Q., Slavin, M., Chen, S. C. A., on behalf of the Global Scedosporium Study Group, (2008). Treatment of Scedosporiosis with Voriconazole: Clinical Experience with 107 Patients. Antimicrob. Agents Chemother. 52: 1743-1750 [Abstract] [Full Text]  
  • Espinel-Ingroff, A., Johnson, E., Hockey, H., Troke, P. (2008). Activities of voriconazole, itraconazole and amphotericin B in vitro against 590 moulds from 323 patients in the voriconazole Phase III clinical studies. J Antimicrob Chemother 61: 616-620 [Abstract] [Full Text]  
  • Caira, M., Girmenia, C., Valentini, C. G., Sanguinetti, M., Bonini, A., Rossi, G., Fianchi, L., Leone, G., Pagano, L. (2008). Scedosporiosis in patients with acute leukemia: a retrospective multicenter report. haematol 93: 104-110 [Abstract] [Full Text]  
  • Yustes, C., Guarro, J. (2005). In Vitro Synergistic Interaction between Amphotericin B and Micafungin against Scedosporium spp.. Antimicrob. Agents Chemother. 49: 3498-3500 [Abstract] [Full Text]  
  • Schaenman, J. M., DiGiulio, D. B., Mirels, L. F., McClenny, N. M., Berry, G. J., Fothergill, A. W., Rinaldi, M. G., Montoya, J. G. (2005). Scedosporium apiospermum Soft Tissue Infection Successfully Treated with Voriconazole: Potential Pitfalls in the Transition from Intravenous to Oral Therapy. J. Clin. Microbiol. 43: 973-977 [Abstract] [Full Text]  
  • Capilla, J., Mayayo, E., Serena, C., Pastor, F. J., Guarro, J. (2004). A novel murine model of cerebral scedosporiosis: lack of efficacy of amphotericin B. J Antimicrob Chemother 54: 1092-1095 [Abstract] [Full Text]  
  • Capilla, J., Guarro, J. (2004). Correlation between In Vitro Susceptibility of Scedosporium apiospermum to Voriconazole and In Vivo Outcome of Scedosporiosis in Guinea Pigs. Antimicrob. Agents Chemother. 48: 4009-4011 [Abstract] [Full Text]  
  • Capilla, J., Serena, C., Pastor, F. J., Ortoneda, M., Guarro, J. (2003). Efficacy of Voriconazole in Treatment of Systemic Scedosporiosis in Neutropenic Mice. Antimicrob. Agents Chemother. 47: 3976-3978 [Abstract] [Full Text]  
  • Steinbach, W. J., Schell, W. A., Miller, J. L., Perfect, J. R. (2003). Scedosporium prolificans Osteomyelitis in an Immunocompetent Child Treated with Voriconazole and Caspofungin, as Well as Locally Applied Polyhexamethylene Biguanide. J. Clin. Microbiol. 41: 3981-3985 [Abstract] [Full Text]  
  • Pearson, M. M, Rogers, P D., Cleary, J. D, Chapman, S. W (2003). Voriconazole: A New Triazole Antifungal Agent. The Annals of Pharmacotherapy 37: 420-432 [Abstract] [Full Text]  
  • Gil-Lamaignere, C., Roilides, E., Mosquera, J., Maloukou, A., Walsh, T. J. (2002). Antifungal Triazoles and Polymorphonuclear Leukocytes Synergize To Cause Increased Hyphal Damage to Scedosporium prolificans and Scedosporium apiospermum. Antimicrob. Agents Chemother. 46: 2234-2237 [Abstract] [Full Text]  
  • Raj, R., Frost, A. E. (2002). Scedosporium apiospermum Fungemia in a Lung Transplant Recipient*. Chest 121: 1714-1716 [Abstract] [Full Text]  
  • Meletiadis, J., Meis, J. F. G. M., Mouton, J. W., Rodriquez-Tudela, J. L., Donnelly, J. P., Verweij, P. E. (2002). In Vitro Activities of New and Conventional Antifungal Agents against Clinical Scedosporium Isolates. Antimicrob. Agents Chemother. 46: 62-68 [Abstract] [Full Text]  
  • Carrillo, A. J., Guarro, J. (2001). In Vitro Activities of Four Novel Triazoles against Scedosporium spp.. Antimicrob. Agents Chemother. 45: 2151-2153 [Abstract] [Full Text]  
  • Espinel-Ingroff, A. (2001). Comparison of the E-test with the NCCLS M38-P Method for Antifungal Susceptibility Testing of Common and Emerging Pathogenic Filamentous Fungi. J. Clin. Microbiol. 39: 1360-1367 [Abstract] [Full Text]  
  • Espinel-Ingroff, A. (2001). In Vitro Fungicidal Activities of Voriconazole, Itraconazole, and Amphotericin B against Opportunistic Moniliaceous and Dematiaceous Fungi. J. Clin. Microbiol. 39: 954-958 [Abstract] [Full Text]  
  • Perea, S., Pennick, G. J., Modak, A., Fothergill, A. W., Sutton, D. A., Sheehan, D. J., Rinaldi, M. G. (2000). Comparison of High-Performance Liquid Chromatographic and Microbiological Methods for Determination of Voriconazole Levels in Plasma. Antimicrob. Agents Chemother. 44: 1209-1213 [Abstract] [Full Text]  
  • Chiou, C. C., Groll, A. H., Walsh, T. J. (2000). New Drugs and Novel Targets for Treatment of Invasive Fungal Infections in Patients with Cancer. The Oncologist 5: 120-135 [Abstract] [Full Text]  
  • Lozano-Chiu, M., Arikan, S., Paetznick, V. L., Anaissie, E. J., Rex, J. H. (1999). Optimizing Voriconazole Susceptibility Testing of Candida: Effects of Incubation Time, Endpoint Rule, Species of Candida, and Level of Fluconazole Susceptibility. J. Clin. Microbiol. 37: 2755-2759 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»