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Journal of Clinical Microbiology, June 1998, p. 1518-1529, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Hospital Specificity, Region Specificity, and Fluconazole Resistance of Candida albicans Bloodstream Isolates

M. A. Pfaller,1 S. R. Lockhart,2 C. Pujol,2 J. A. Swails-Wenger,2 S. A. Messer,1 M. B. Edmond,3 R. N. Jones,1 R. P. Wenzel,3 and D. R. Soll2,*

Departments of Pathology1 and Biological Sciences,2 University of Iowa, Iowa City, Iowa 52242, and Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia 23298-00533

Received 12 November 1997/Returned for modification 26 December 1997/Accepted 6 March 1998

In a survey of bloodstream infection (BSI) isolates across the continental United States, 162 Candida albicans isolates were fingerprinted with the species-specific probe Ca3 and the patterns were analyzed for relatedness with a computer-assisted system. The results demonstrate that particular BSI strains are more highly concentrated in particular geographic locales and that established BSI strains are endemic in some, but not all, hospitals in the study and undergo microevolution in hospital settings. The results, however, indicate no close genetic relationship among fluconazole-resistant BSI isolates in the collection, either from the same geographic locale or the same hospital. This study represents the first of three fingerprinting studies designed to analyze the origin, genetic relatedness, and drug resistance of Candida isolates responsible for BSI.

* Corresponding author. Mailing address: David R. Soll Department of Biological Sciences, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-1111. Fax: (319) 335-2772. E-mail: drs{at}biovax.biology.uiowa.edu.

Journal of Clinical Microbiology, June 1998, p. 1518-1529, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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