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Journal of Clinical Microbiology, June 1998, p. 1767-1768, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Low-Level Vancomycin Resistance in Clostridium innocuum

Francine Mory,1,* Alain Lozniewski,1 Veronique David,2 Jean Philippe Carlier,3 Luc Dubreuil,4 and Roland Leclercq2

Laboratoire de Bactériologie, Hôpital Central, Centre Hospitalier et Universitaire, 54035 Nancy Cedex,1 Laboratoire de Bactériologie-Virologie, Centre Hospitalier et Universitaire Henri Mondor, 94010 Créteil Cedex,2 Centre National de Référence des Anaérobies, Institut Pasteur, 75724 Paris Cedex 15,3 and Laboratoire de Microbiologie, Faculté de Pharmacie, 59006 Lille Cedex,4 France

Received 15 December 1997/Returned for modification 24 February 1998/Accepted 12 March 1998

Low-level vancomycin resistance was observed for 28 clinical Clostridium innocuum isolates and C. innocuum NCIB 10674, whereas teicoplanin was active. DNA from three clinical isolates and the type strain could not be amplified by PCR with primers specific for the genes vanA, vanB, and vanC, suggesting that C. innocuum is intrinsically resistant to vancomycin.

* Corresponding author. Mailing address: Laboratoire de Bacteriologie, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy Cedex, France. Phone: (33) 3-83-85-14-34. Fax: (33) 3-83-85-26-73.

Journal of Clinical Microbiology, June 1998, p. 1767-1768, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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