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Journal of Clinical Microbiology, June 1998, p. 1811-1813, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Defective Human T-Cell Lymphotropic Virus Type I (HTLV-I) Provirus in 10 Chilean Seronegative Patients with Tropical Spastic Paraparesis or HTLV-I-Associated Myelopathy

Eugenio Ramirez,1,* Luis Cartier,2 Maritza Rios,1,3 and Jorge Fernandez1

Section of Virology, Department of Health Laboratories, Public Health Institute of Chile,1 and Departments of Neurology2 and Microbiology,3 Faculty of Medicine, University of Chile, Santiago, Chile

Received 22 August 1997/Returned for modification 12 November 1997/Accepted 23 March 1998

We studied the presence of tax and ltr genes from human T-cell lymphotropic virus type I (HTLV-I) provirus in the peripheral blood mononuclear cells from 15 seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy by PCR. Only a region of the tax gene from 10 patients was amplified. The nucleotide homologies of six Chilean isolates to the ATK-1 clone ranged between 98.7 and 99.4%.

* Corresponding author. Mailing address: Section of Virology, Public Health Institute of Chile, Avenida Marathon 1000, Santiago, Chile. Phone and Fax: 562-2396966. E-mail: eramirez{at}ispch.cl.

Journal of Clinical Microbiology, June 1998, p. 1811-1813, Vol. 36, No. 6
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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