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Journal of Clinical Microbiology, July 1998, p. 2084-2086, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Low-Level Viremia and Intracellular Expression of Hepatitis B Surface Antigen (HBsAg) in HBsAg Carriers with Concurrent Hepatitis C Virus Infection

Chia-Ming Chu,* Chau-Ting Yeh, and Yun-Fan Liaw

Liver Research Unit, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan

Received 14 January 1998/Returned for modification 3 March 1998/Accepted 30 March 1998

Assays of hepatitis B virus (HBV) replication and antigen expression in HBV surface antigen (HBsAg) carriers with concurrent hepatitis C or D virus (HCV or HDV) infection revealed that HCV and HDV can suppress HBV replication but that HCV also substantially suppresses HBV surface protein expression. HBsAg carriers with concurrent HCV infection thus have low-level viremia and intracellular HBsAg.

* Corresponding author. Mailing address: Liver Research Unit, Chang Gung Memorial Hospital, 199 Tung Hwa North Rd., Taipei, Taiwan 105. Phone: 886-3-3281200, ext. 8120. Fax: 886-3-3282824. E-mail: gi31208108{at}adm.cgmh.com.tw.

Journal of Clinical Microbiology, July 1998, p. 2084-2086, Vol. 36, No. 7
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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