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Journal of Clinical Microbiology, August 1998, p. 2369-2370, Vol. 36, No. 8
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Stephan Miehlke,1,* Alexander Meining,2 Andrea Morgner,1 Ekkehard Bayerdörffer,1 Norbert Lehn,3 Manfred Stolte,4 David Y. Graham,5 and Mae F. Go5

Medical Department I, Technical University, Dresden,1 Medical Department II, Technical University, Munich,2 Institute of Clinical Microbiology, University of Regensburg, Regensburg,3 and Institute of Pathology, Klinikum Bayreuth, Bayreuth,4 Germany, and Department of Medicine, Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas5

Received 5 December 1997/Returned for modification 17 February 1998/Accepted 24 April 1998

The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. The vacA s1 genotype was significantly associated with, but not predictive of, the presence of vacuolating cytotoxin activity.

* Corresponding author. Mailing address: Medical Department I, Technical University Dresden, Fetscherstr. 74, D-01307 Dresden, Germany. Phone: 49 351 458 5645. Fax: 49 351 458 4394. E-mail: stephan.miehlke{at}t-online.de.

Journal of Clinical Microbiology, August 1998, p. 2369-2370, Vol. 36, No. 8
0095-1137/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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