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Journal of Clinical Microbiology, October 1999, p. 3405-3408, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Transmission of an Azole-Resistant Isogenic Strain of Candida albicans among Human Immunodeficiency Virus-Infected Family Members with Oropharyngeal Candidiasis

Frank-Michael C. Müller,1,2,* Miki Kasai,1 Andrea Francesconi,1 Beth Brillante,1 Maureen Roden,1 Joanne Peter,1 Stephen J. Chanock,1 and Thomas J. Walsh1,*

Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland,1 and Institut für Molekulare Infektionsbiologie, Universität Würzburg, Würzburg, Germany2

Received 18 March 1999/Returned for modification 29 April 1999/Accepted 22 July 1999

We report transmission of an azole-resistant, isogenic strain of Candida albicans in a human immunodeficiency virus (HIV)-infected family of two children with symptomatic oropharyngeal candidiasis and a mother with asymptomatic colonization over a 5-year period. These findings were confirmed by three different molecular epidemiology methods: interrepeat PCR, Southern hybridization with a C. albicans repetitive element 2 probe, and electrophoretic karyotyping. This study contributes to an evolving understanding of the mode of transmission of C. albicans, particularly in children, and underscores the importance of monitoring specimens from family members of HIV-infected patients.

* Corresponding author. Mailing address for Frank-Michael C. Müller: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany. Phone: 49-931-312575. Fax: 49-931-312578. E-mail: fmmueller{at}mail.uni-wuerzburg.de. Mailing address for Thomas J. Walsh: Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892. Phone: (301) 402-0023. Fax: (301) 402-0575. E-mail: walsht{at}mail.nih.gov.

Journal of Clinical Microbiology, October 1999, p. 3405-3408, Vol. 37, No. 10
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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