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Journal of Clinical Microbiology, November 1999, p. 3713-3717, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
Molecular Markers Reveal Exclusively Clonal
Reproduction in Trichophyton rubrum
Y.
Gräser,*
J.
Kühnisch, and
W.
Presber
Department of Microbiology and Hygiene
(Charité-Virchow), Humboldt University, Berlin, Germany
Received 14 April 1999/Returned for modification 24 May
1999/Accepted 28 June 1999
Genotypic variability among 96 Trichophyton rubrum
strains which displayed different colony morphologies and were
collected from four continents was investigated. Twelve markers
representing 57 loci were analyzed by PCR fingerprinting, amplified
fragment length polymorphism, and random amplified monomorphic DNA
markers. Interestingly, none of the methods used revealed any DNA
polymorphism, indicating a strictly clonal mode of reproduction and a
strong adaptation to human skin.
*
Corresponding author. Mailing address: Institut
für Mikrobiologie und Hygiene, Universitätsklinikum
Charité-Virchow, Campus Mitte, Humboldt Universität zu
Berlin, Dorotheenstr. 96, D-10117 Berlin, Germany. Phone:
49-30-20934799. Fax: 49-30-20934703. E-mail: yvonne.graeser{at}charite.de.
Journal of Clinical Microbiology, November 1999, p. 3713-3717, Vol. 37, No. 11
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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