This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pusterla, N.
Right arrow Articles by Madigan, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pusterla, N.
Right arrow Articles by Madigan, J. E.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, December 1999, p. 4042-4044, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Quantitative Evaluation of Ehrlichial Burden in Horses after Experimental Transmission of Human Granulocytic Ehrlichia Agent by Intravenous Inoculation with Infected Leukocytes and by Infected Ticks

Nicola Pusterla,1,* Christian M. Leutenegger,1 Joon-Seok Chae,1 Hans Lutz,2 Robert B. Kimsey,3 J. Stephen Dumler,4 and John E. Madigan1

Department of Medicine and Epidemiology, School of Veterinary Medicine,1 and Department of Entomology, College of Agriculture,3 University of California, Davis, California 95616; Department of Veterinary Internal Medicine, University of Zurich, CH-8057 Zurich, Switzerland2; and Department of Pathology, The Johns Hopkins Medical University School of Medicine, Baltimore, Maryland 212014

Received 26 April 1999/Returned for modification 17 June 1999/Accepted 17 September 1999

This paper describes the kinetics of the human granulocytic ehrlichiosis agent in the blood of horses experimentally infected by intravenous inoculation with infected leukocytes and by infected ticks as evaluated by using a real-time quantitative PCR assay. The data obtained indicated differences in the period of incubation, duration of rickettsemia, and initial and maximal ehrlichial loads between the two routes of infection.

* Corresponding author. Mailing address: School of Veterinary Medicine, University of California, Davis, CA 95616. Phone: (530) 752-2371. Fax: (530) 752-0414. E-mail: npusterla{at}ucdavis.edu.

Journal of Clinical Microbiology, December 1999, p. 4042-4044, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Johns, J. L., MacNamara, K. C., Walker, N. J., Winslow, G. M., Borjesson, D. L. (2009). Infection with Anaplasma phagocytophilum Induces Multilineage Alterations in Hematopoietic Progenitor Cells and Peripheral Blood Cells. Infect. Immun. 77: 4070-4080 [Abstract] [Full Text]  
  • Zeman, P., Jahn, P. (2009). An entropy-optimized multilocus approach for characterizing the strains of Anaplasma phagocytophilum infecting horses in the Czech Republic. J Med Microbiol 58: 423-429 [Abstract] [Full Text]  
  • Butler, C. M., Nijhof, A. M., Jongejan, F., van der Kolk, J. H. (2008). Anaplasma phagocytophilum infection in horses in the Netherlands. Vet Rec. 162: 216-217 [Full Text]  
  • Levin, M. L., Coble, D. J., Ross, D. E. (2004). Reinfection with Anaplasma phagocytophilum in BALB/c Mice and Cross-Protection between Two Sympatric Isolates. Infect. Immun. 72: 4723-4730 [Abstract] [Full Text]  
  • Eremeeva, M. E., Dasch, G. A., Silverman, D. J. (2003). Evaluation of a PCR Assay for Quantitation of Rickettsia rickettsii and Closely Related Spotted Fever Group Rickettsiae. J. Clin. Microbiol. 41: 5466-5472 [Abstract] [Full Text]  
  • Kim, H.-Y., Mott, J., Zhi, N., Tajima, T., Rikihisa, Y. (2002). Cytokine Gene Expression by Peripheral Blood Leukocytes in Horses Experimentally Infected with Anaplasma phagocytophila. CVI 9: 1079-1084 [Abstract] [Full Text]  
  • Zhi, N., Ohashi, N., Tajima, T., Mott, J., Stich, R. W., Grover, D., Telford III, S. R., Lin, Q., Rikihisa, Y. (2002). Transcript Heterogeneity of the p44 Multigene Family in a Human Granulocytic Ehrlichiosis Agent Transmitted by Ticks. Infect. Immun. 70: 1175-1184 [Abstract] [Full Text]  
  • Martin, M. E., Caspersen, K., Dumler, J. S. (2001). Immunopathology and Ehrlichial Propagation Are Regulated by Interferon-{{gamma}} and Interleukin-10 in a Murine Model of Human Granulocytic Ehrlichiosis. Am. J. Pathol. 158: 1881-1888 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»