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Journal of Clinical Microbiology, December 1999, p. 4156-4157, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Simultaneous Infection with Two Drug-Susceptible Mycobacterium tuberculosis Strains in an Immunocompetent Host

Marion Pavlic, Franz Allerberger, Manfred P. Dierich, and Wolfgang M. Prodinger*

Institut für Hygiene, University of Innsbruck, Innsbruck, Austria

Received 4 June 1999/Returned for modification 22 July 1999/Accepted 18 August 1999

An important assumption for DNA fingerprinting of Mycobacterium tuberculosis is that patients are infected with only one strain at a time. Nonetheless, we demonstrate a case of simultaneous infection with two drug-susceptible strains of M. tuberculosis in an immunocompetent patient by IS6110 restriction fragment length polymorphism and spoligotyping. Epidemiological data prove the patient's involvement in two independent clusters. Thus, double infections should be suspected with fingerprints showing divergent band intensities.

* Corresponding author. Mailing address: Institut für Hygiene, University of Innsbruck, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria. Phone: 43 512 507 3424. Fax: 43 512 507 2870. E-mail: wolfgang.prodinger{at}uibk.ac.at.

Journal of Clinical Microbiology, December 1999, p. 4156-4157, Vol. 37, No. 12
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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