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Journal of Clinical Microbiology, February 1999, p. 445-446, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Hemolysin as a Virulence Factor for Systemic Infection with Isolates of Mycobacterium avium Complex

Joel N. Maslow,1,* David Dawson,2 Elizabeth A. Carlin,1 and Steven M. Holland3

Infectious Diseases Section, Medical Service, VA Medical Center, and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts1; Laboratory of Microbiology and Pathology, Queensland Health, Brisbane, Australia2; and Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland3

Received 28 May 1998/Returned for modification 7 July 1998/Accepted 9 November 1998

Isolates of the Mycobacterium avium complex were examined for hemolysin expression. Only invasive isolates of M. avium were observed to be hemolytic (P < 0.001), with activity the greatest for isolates of serovars 4 and 8. Thus, M. avium hemolysin appears to represent a virulence factor necessary for invasive disease.

* Corresponding author. Mailing address: Research Service (151), VA Medical Center, 150 South Huntington Ave., Boston, MA 02130. Phone: (617) 232-9500, ext. 5576. Fax: (617) 278-4540. E-mail: maslow.joel_n.md{at}boston.va.gov.

Journal of Clinical Microbiology, February 1999, p. 445-446, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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