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Journal of Clinical Microbiology, February 1999, p. 467-470, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Utility of PCR Assay in Diagnosis of En-Plaque Tuberculoma of the Brain

K. K. Singh,1 M. D. Nair,2 K. Radhakrishnan,2 and J. S. Tyagi1,*

Department of Biotechnology, All India Institute of Medical Sciences, New Delhi,1 and Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram,2 India

Received 12 August 1998/Returned for modification 15 September 1998/Accepted 16 November 1998

This is the first report of a case in which diagnosis of en-plaque tuberculoma on the basis of magnetic resonance imaging (MRI) findings was confirmed by a Mycobacterium tuberculosis complex-specific PCR assay of cerebrospinal fluid. The accuracy of the diagnosis was supported by good response to antitubercular drugs, which was shown by repeat MRI studies performed after treatment.

* Corresponding author. Mailing address: Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar-110029, New Delhi, India. Phone: 91-11-6593549. Fax: 91-11-6862663. E-mail: jst{at}aiims.ernet.in or jstyagi{at}hotmail.com.

Journal of Clinical Microbiology, February 1999, p. 467-470, Vol. 37, No. 2
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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