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Journal of Clinical Microbiology, April 1999, p. 1045-1048, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Helicobacter pylori Can Be Induced To Assume the Morphology of Helicobacter heilmannii

Paul T. Fawcett,* Kathleen M. Gibney, and Kathleen M. B. Vinette

Immunology Laboratory, Department of Clinical Science, duPont Hospital for Children, Wilmington, Delaware

Received 22 September 1998/Returned for modification 8 December 1998/Accepted 7 January 1999

Cultures of Helicobacter pylori obtained from the American Type Culture Collection (strain 43504) were grown as isolated colonies or lawns on blood agar plates and in broth culture with constant shaking. Examination of bacterial growth with Gram-stained fixed preparation and differential interference contrast microscopy on wet preparations revealed that bacteria grown on blood agar plates had a morphology consistent with that normally reported for H. pylori whereas bacteria from broth cultures had the morphologic appearance of Helicobacter heilmannii. Bacteria harvested from blood agar plates assumed an H. heilmannii-like morphology when transferred to broth cultures, and bacteria from broth cultures grew with morphology typical of H. pylori when grown on blood agar plates. Analysis by PCR of bacteria isolated from blood agar plates and broth cultures indicated that a single strain of bacteria (H. pylori) was responsible for both morphologies.

* Corresponding author. Mailing address: duPont Hospital for Children, Department of Clinical Science, P.O. Box 269, Wilmington, DE 19899. Phone: (302) 651-6776. Fax: (302) 651-6881. E-mail: pfawcett{at}nemours.org.

Journal of Clinical Microbiology, April 1999, p. 1045-1048, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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