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Journal of Clinical Microbiology, April 1999, p. 1182-1185, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Evidence for Nasal Carriage of Methicillin-Resistant Staphylococci Colonizing Intravascular Devices

Noëlle Barbier Frebourg,* Bruno Cauliez, and Jean-François Lemeland

Groupe de Recherche sur les Antimicrobiens et Microorganismes (GRAM), CHU de Rouen, Hôpital Charles Nicolle, 76031 Rouen Cedex, France

Received 3 August 1998/Returned for modification 3 November 1998/Accepted 10 January 1999

Nasal surveillance cultures were performed for 54 patients exhibiting >= 103 CFU of methicillin-resistant coagulase-negative staphylococci per ml in central venous catheter (CVC) rinse cultures over a 6-month period. Forty-two of the nasal cultures yielded growth of methicillin-resistant coagulase-negative staphylococci, and 33 of the 42 cultures contained organisms that belonged to the same species as the CVC isolates. Of the 33 same-species isolates, 20 appeared to be identical strains by pulsed-field gel electrophoresis analysis. These data suggest that measures should be taken to reduce cross-contamination between the respiratory tract and intravascular devices. However, the potential interest in detecting methicillin-resistant coagulase-negative staphylococcus carriage in high-risk patients is hampered by the lack of sensitivity of nasal surveillance cultures.

* Corresponding author. Mailing address: CHU de Rouen, Hôpital Charles Nicolle, Laboratoire de Bactériologie, 1, Rue de Germont, 76031 Rouen Cedex, France. Phone: 33 2 32 88 80 52. Fax: 33 2 32 88 80 24. E-mail: bacteriologie{at}chu-rouen.fr.

Journal of Clinical Microbiology, April 1999, p. 1182-1185, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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