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Journal of Clinical Microbiology, April 1999, p. 1203-1205, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Allelic Diversity of the Helicobacter pylori Vacuolating Cytotoxin Gene in South Africa: Rarity of the vacA s1a Genotype and Natural Occurrence of an s2/m1 Allele

D. P. Letley,1,2 A. Lastovica,3,4 J. A. Louw,4,5 C. J. Hawkey,1 and J. C. Atherton1,2,*

Division of Gastroenterology1 and Institute of Infections and Immunity,2 University of Nottingham, Nottingham, United Kingdom, and Red Cross Children's Hospital,3 Groote Schuur Hospital,5 and University of Cape Town,4 Cape Town, South Africa

Received 13 October 1998/Returned for modification 23 November 1998/Accepted 11 January 1999

We describe the rarity of Helicobacter pylori strains of vacuolating cytotoxin type s1a (the type most commonly associated with peptic ulceration in the United States) among black and mixed-race South Africans. We also provide the first description of a naturally occurring strain with the vacA allelic structure s2/m1.

* Corresponding author. Mailing address: Division of Gastroenterology, Queen's Medical Centre, University Hospital, Clifton Boulevard, Nottingham NG7 2UH, United Kingdom. Phone: (44) 115 9249924. Fax: (44) 115 9422232. E-mail: John.Atherton{at}nottingham.ac.uk.

Journal of Clinical Microbiology, April 1999, p. 1203-1205, Vol. 37, No. 4
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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