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Journal of Clinical Microbiology, July 1999, p. 2348-2349, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Analysis of vacA, cagA, and IS605 Genotypes and Those Determined by PCR Amplification of DNA between Repetitive Sequences of Helicobacter pylori Strains Isolated from Patients with Nonulcer Dyspepsia or Mucosa-Associated Lymphoid Tissue Lymphoma

Nathalie E. M. van Doorn,1 Ferry Namavar,1,* Leen-Jan van Doorn,2 Zarmina Durrani,3 Ernst J. Kuipers,4 and Christina M. J. E. Vandenbroucke-Grauls1

Department of Medical Microbiology, Vrije Universiteit, Amsterdam,1 Delft Diagnostic Laboratory, Delft,2 and Department of Gastroenterology, Vrije Universiteit Hospital, Amsterdam,4 The Netherlands, and Division of Bacteriology, National Institute of Biological Standards and Control, Potters Bar, United Kingdom3

Received 18 November 1998/Returned for modification 25 January 1999/Accepted 26 March 1999

The vacA s and m genotypes and the presence of cagA and IS605 were determined in Helicobacter pylori strains from patients with mono- and multiple infections. Surprisingly, these genetic markers were not associated with nonulcer dyspepsia or mucosa-associated lymphoid tissue lymphoma. The presence of cagA correlated with the presence of the vacA s1 allele (P < 0.05), whereas the presence of IS605 was associated with the presence of the s2 allele (P < 0.05).

* Corresponding author. Mailing address: Vrije Universiteit, Department of Medical Microbiology, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. Phone: 31 (20) 4448296. Fax: 31 (20) 4448318. E-mail: F.Namavar.mm{at}med.vu.nl.

Journal of Clinical Microbiology, July 1999, p. 2348-2349, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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