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Journal of Clinical Microbiology, July 1999, p. 2371-2372, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Molecular Epidemiology of Hepatitis C Virus Infection in an Area of Hyperendemicity in Southern Italy: a Population-Based Study

Alberto R. Osella,1,* Laura Sonzogni,2 Aldo Cavallini,3 Luciana Foti,2 Vito Guerra,1 Alfredo Di Leo,3 Mario U. Mondelli,4 Giovanni Misciagna,1 and Enrico M. Silini2,5

Laboratory of Epidemiology and Biostatistics1 and Laboratory of Biochemistry,3 IRCCS "Saverio De Bellis," 70013 Castellana Grotte (BA), Associazione Studio Avanzato Epatiti Virali (A.S.A.E.V.), 24040 Bonate Sotto (BG),2 Departments of Pathology5 and Infectious Diseases,4 University and IRCCS "S. Matteo," 27100 Pavia, Italy

Received 23 November 1998/Returned for modification 4 March 1999/Accepted 16 April 1999

In a cohort of subjects from Italy, anti-hepatitis C virus (HCV) and HCV RNA [HCV(+) subgroup] prevalences were 24.6 and 79.6%, respectively. HCV types 1b and 2a/c accounted for 95% of infections. Adjusted alanine aminotransferase levels were higher in males than in females and in RNA-positive subjects than in RNA-negative subjects regardless of HCV type. Genotype distribution was unrelated to demographic variables.

* Corresponding author. Mailing address: Laboratory of Epidemiology and Biostatistics, IRCCS "Saverio de Bellis," Via F. Valente, 4, 70013 Castellana Grotte (BA), Italy. Phone: 39 080 4960248. Fax: 39 080 4961394. E-mail: irccsbiblio{at}mail.media.it.

Journal of Clinical Microbiology, July 1999, p. 2371-2372, Vol. 37, No. 7
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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