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Journal of Clinical Microbiology, August 1999, p. 2446-2449, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Involvement of Enterotoxins G and I in Staphylococcal Toxic Shock Syndrome and Staphylococcal Scarlet Fever

Sophie Jarraud,1 Grégoire Cozon,2 François Vandenesch,1 Michèle Bes,1 Jerome Etienne,1 and Gerard Lina1,*

Centre National de Référence des Toxémies Staphylococciques, Faculté de Médecine, 69372 Lyon Cedex 08,1 and Unité d'Immunologie, Hôpital de la Croix-Rousse, 69317 Lyon Cedex 04,2 France

Received 12 February 1999/Returned for modification 19 March 1999/Accepted 27 April 1999

We investigated the involvement of the recently described staphylococcal enterotoxins G and I in toxic shock syndrome. We reexamined Staphylococcus aureus strains isolated from patients with menstrual and nonmenstrual toxic shock syndrome (nine cases) or staphylococcal scarlet fever (three cases). These strains were selected because they produced none of the toxins known to be involved in these syndromes (toxic shock syndrome toxin 1 and enterotoxins A, B, C, and D), enterotoxin E or H, or exfoliative toxin A or B, despite the fact that superantigenic toxins were detected in a CD69-specific flow cytometry assay measuring T-cell activation. Sets of primers specific to the enterotoxin G and I genes (seg and sei, respectively) were designed and used for PCR amplification. All of the strains were positive for seg and sei. Sequence analysis confirmed that the PCR products, corresponded to the target genes. We suggest that staphylococcal enterotoxins G and I may be capable of causing human staphylococcal toxic shock syndrome and staphylococcal scarlet fever.

* Corresponding author. Mailing address: Faculté de Médecine, Laboratoire de Bactériologie, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France. Phone: 33 (0) 478 77 86 57. Fax: 33 (0) 478 77 86 58. E-mail: geralina{at}univ-lyon1.fr.

Journal of Clinical Microbiology, August 1999, p. 2446-2449, Vol. 37, No. 8
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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