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Journal of Clinical Microbiology, September 1999, p. 3013-3016, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Hepatitis B Virus (HBV) Mutations Associated with Resistance to Lamivudine in Patients Coinfected with HBV and Human Immunodeficiency Virus

Vincent Thibault,* Yves Benhamou, Christophe Seguret, Marie Bochet, Christine Katlama, François Bricaire, Pierre Opolon, Thierry Poynard, and Henri Agut

Laboratoire de Virologie, Service d'Hépato-Gastro-Entérologie, Service des Maladies Infectieuses, Groupe Hospitalier Pitié-Salpêtrière, 75013 Paris, France

Received 11 January 1999/Returned for modification 8 April 1999/Accepted 7 June 1999

Mutations associated with hepatitis B virus (HBV) resistance to lamivudine have not been extensively addressed in human immunodeficiency virus (HIV)-HBV coinfection. We have studied the HBV polymerase sequences from nine coinfected patients who experienced HBV recurrence while under lamivudine treatment. In seven of these nine patients, Met550, belonging to the highly conserved YMDD motif, was mutated to Val and was associated with a substitution of Met for Leu526 in each case. In the two remaining patients, we found a Met550-to-Ile change that was associated in only one case with a Leu526-to-Met mutation. No mutation was observed in three control patients not receiving lamivudine. This study demonstrates the emergence of particular genetic profiles in HBV-HIV-coinfected patients experiencing a loss of control of HBV infection despite high doses of lamivudine.

* Corresponding author. Mailing address: Groupe Hospitalier Pitié-Salpêtrière, Laboratoire de Virologie-CERVI, 83 Bd. de l'hôpital, 75013 Paris, France. Phone: 33 1 42 17 74 26. Fax: 33 1 42 17 74 11. E-mail: vincent.thibault{at}psl.ap-hop-paris.fr.

Journal of Clinical Microbiology, September 1999, p. 3013-3016, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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