This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holmes, G. F.
Right arrow Articles by Merz, W. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holmes, G. F.
Right arrow Articles by Merz, W. G.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, September 1999, p. 3059-3061, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Recurrent, Disseminated Mycobacterium marinum Infection Caused by the Same Genotypically Defined Strain in an Immunocompromised Patient

G. Frank Holmes, Susan M. Harrington, Mark J. Romagnoli, and William G. Merz*

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-7093

Received 15 January 1999/Returned for modification 11 March 1999/Accepted 27 May 1999

An 81-year-old male with myasthenia gravis developed a cutaneous infection with Mycobacterium marinum, which apparently resolved following local heat therapy. Five months later, the patient developed new skin lesions and pancytopenia. M. marinum was isolated from his bone marrow. Pulsed-field gel electrophoresis was performed to determine if the skin and bone marrow isolates were clonally related. Digestion of the genomic DNA with the restriction enzymes SpeI and AseI yielded indistinguishable banding patterns. An epidemiologically unrelated control strain showed significant banding differences. The results suggest that the patient's recurrent, disseminated infection was due to recrudescence of his initial infection rather than reinfection by another strain.

* Corresponding author. Mailing address: Microbiology, Meyer B1-193, Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21287-7093. Phone: (410) 955-5077. Fax: (410) 614-8087. E-mail: wmerz{at}pathlan.path.jhu.edu.

Journal of Clinical Microbiology, September 1999, p. 3059-3061, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pignone, M., Greth, K. M., Cooper, J., Emerson, D., Tang, J. (2006). Identification of Mycobacteria by Matrix-Assisted Laser Desorption Ionization-Time-of-Flight Mass Spectrometry.. J. Clin. Microbiol. 44: 1963-1970 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»