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Journal of Clinical Microbiology, September 1999, p. 3068-3071, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Interactions between Methicillin and Vancomycin in Methicillin-Resistant Staphylococcus aureus Strains Displaying Different Phenotypes of Vancomycin Susceptibility

Robin A. Howe,1,* Mandy Wootton,1,2 Peter M. Bennett,2 Alasdair P. MacGowan,1 and Timothy R. Walsh2

Bristol Centre for Antimicrobial Research and Evaluation, Department of Medical Microbiology, Southmead Health Services NHS Trust, Westbury-on-Trym, Bristol BS10 5NB,1 and Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD,2 United Kingdom

Received 30 November 1998/Returned for modification 2 April 1999/Accepted 9 June 1999

Vancomycin-sensitive, -intermediate, and -heterointermediate methicillin-resistant Staphylococcus aureus isolates were tested by using E-tests to explore the interaction of methicillin and vancomycin. For the vancomycin-intermediate and -heterointermediate strains both drugs showed antagonism at concentrations below their MICs but synergy at methicillin concentrations near the MIC. This property could be used to screen for heterointermediate S. aureus strains.

* Corresponding author. Mailing address: Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, United Kingdom. Phone: 44 (0)117-959-5651. Fax: 44 (0)117-959-3154. E-mail: Staff{at}bcare.org.uk.

Journal of Clinical Microbiology, September 1999, p. 3068-3071, Vol. 37, No. 9
0095-1137/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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