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Journal of Clinical Microbiology, November 2000, p. 4246-4248, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Marked Differences in Quantity of Infectious Human Immunodeficiency Virus Type 1 Detected in Persons with Controlled Plasma Viremia by a Simple Enhanced Culture Method

Cécile L. Tremblay, Françoise Giguel, Debra P. Merrill, Johnson T. Wong, Eric Rosenberg, Spyros Kalams, Bruce D. Walker, Richard T. D'Aquila, and Martin S. Hirsch*

AIDS Research Center, Infectious Diseases Unit and Immunopathology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

Received 1 March 2000/Returned for modification 29 June 2000/Accepted 16 August 2000

Culture of autologous CD4 lymphocytes from peripheral blood mononuclear cells compared favorably with two other methods for the measurement of cell-associated human immunodeficiency virus type 1 (HIV-1). For subjects with undetectable HIV-1 RNA levels in plasma, there was a 10,000-fold range of cell-associated virus detected. This method provides a simple and reproducible means for monitoring cell-associated HIV-1.

* Corresponding author. Mailing address: Infectious Disease Unit, Gray 5, Massachusetts General Hospital, Fruit St., Boston, MA 02114. Phone: (617) 726-3815. Fax: (617) 726-7416. E-mail: hirsch.martin{at}mgh.harvard.edu.

Journal of Clinical Microbiology, November 2000, p. 4246-4248, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kran, A.-M. B., Jonassen, T. O., Sannes, M., Jakobsen, K., Lind, A., Maeland, A., Holberg-Petersen, M. (2009). Overestimation of Human Immunodeficiency Virus Type 1 Load Caused by the Presence of Cells in Plasma from Plasma Preparation Tubes. J. Clin. Microbiol. 47: 2170-2174 [Abstract] [Full Text]  


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