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Journal of Clinical Microbiology, November 2000, p. 4264-4265, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Can Pooling Be Used for Seroprevalence Studies of Hepatitis C?

G. M. Stephens,1,2,3 J. M. Raboud,4,5 L. Karakas,1 and C. H. Sherlock1,2,3,*

Diagnostic Virology and Reference Laboratory,1 Department of Pathology and Laboratory Medicine,2 and Department of Health Care and Epidemiology,5 University of British Columbia, Department of Pathology and Laboratory Medicine, St. Paul's Hospital,3 and Canadian HIV Trials Network,4 Vancouver, British Columbia, Canada

Received 22 June 2000/Returned for modification 15 July 2000/Accepted 18 August 2000

Two hepatitis C antibody assays were used to test diluted positive sera. Dilutions of 1 in 5, 1 in 10, and 1 in 20 all resulted in loss of reactivity, with the greatest losses occurring in samples with low and moderate reactivities. These results disqualify pooling as a strategy for seroprevalence studies and screening programs.

* Corresponding author. Mailing address: UBC Diagnostic Virology and Reference Laboratory, St. Paul's Hospital, 632-1081 Burrard St., Vancouver, British Columbia V6Z 1Y6, Canada. Phone: (604) 806-8426. Fax: (604) 806-8421. E-mail: csherloc{at}interchange.ubc.ca.

Journal of Clinical Microbiology, November 2000, p. 4264-4265, Vol. 38, No. 11
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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