This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gieffers, J.
Right arrow Articles by Maass, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gieffers, J.
Right arrow Articles by Maass, M.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, February 2000, p. 881-882, Vol. 38, No. 2
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Failure To Detect Chlamydia pneumoniae in Brain Sections of Alzheimer's Disease Patients

Jens Gieffers,1,* Erich Reusche,2 Werner Solbach,1 and Matthias Maass1

Institute of Medical Microbiology and Hygiene1 and Institute of Pathology,2 Medical University of Lübeck, D-23538 Lübeck, Germany

Received 23 July 1999/Returned for modification 8 September 1999/Accepted 1 November 1999

A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens. From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.

* Corresponding author. Mailing address: Institute of Medical Microbiology and Hygiene, Medical University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. Phone: 49 (451) 500-2818. Fax: 49 (451) 500-2808. E-mail: gieffers{at}hygiene.mu-luebeck.de.

Journal of Clinical Microbiology, February 2000, p. 881-882, Vol. 38, No. 2
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Mori, I., Yokochi, T., Koide, N., Sugiyama, T., Yoshida, T., Kimura, Y., Naiki, H., Matsubara, R., Takeuchi, T., Nishiyama, Y. (2004). PCR Search for the Herpes Simplex Virus Type 1 Genome in Brain Sections of Patients with Familial Alzheimer's Disease. J. Clin. Microbiol. 42: 936-937 [Full Text]  
  • Strandberg, T. E., Pitkala, K. H., Linnavuori, K. H., Tilvis, R. S. (2003). Impact of Viral and Bacterial Burden on Cognitive Impairment in Elderly Persons With Cardiovascular Diseases. Stroke 34: 2126-2131 [Abstract] [Full Text]  
  • Taylor, G. S., Vipond, I. B., Paul, I. D., Matthews, S., Wilcock, G. K., Caul, E. O. (2002). Failure to correlate C. pneumoniae with late onset Alzheimer's disease. Neurology 59: 142-143 [Full Text]  
  • Tondella, M. L. C., Talkington, D. F., Holloway, B. P., Dowell, S. F., Cowley, K., Soriano-Gabarro, M., Elkind, M. S., Fields, B. S. (2002). Development and Evaluation of Real-Time PCR-Based Fluorescence Assays for Detection of Chlamydiapneumoniae. J. Clin. Microbiol. 40: 575-583 [Abstract] [Full Text]  
  • Smieja, M., Mahony, J. B., Goldsmith, C. H., Chong, S., Petrich, A., Chernesky, M. (2001). Replicate PCR Testing and Probit Analysis for Detection and Quantitation of Chlamydia pneumoniae in Clinical Specimens. J. Clin. Microbiol. 39: 1796-1801 [Abstract] [Full Text]  
  • Hammerschlag, M. R., Ke, Z., Lu, F., Roblin, P., Boman, J., Kalman, B. (2000). Is Chlamydia pneumoniae Present in Brain Lesions of Patients with Multiple Sclerosis?. J. Clin. Microbiol. 38: 4274-4276 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»