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Journal of Clinical Microbiology, February 2000, p. 926-928, Vol. 38, No. 2
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Temperature-Sensitive Strain of Cryptococcus neoformans Producing Hyphal Elements in a Feline Nasal Granuloma

D. A. Bemis,1,* D. J. Krahwinkel,2 L. A. Bowman,3,dagger P. Mondon,4 and K. J. Kwon-Chung4

Department of Comparative Medicine,1 Department of Small Animal Clinical Sciences,2 and Department of Pathology,3 College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, and Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 208924

Received 26 July 1999/Returned for modification 31 August 1999/Accepted 14 October 1999

We report the isolation of a temperature-sensitive, serotype A, mating type alpha  strain of Cryptococcus neoformans from a case of nasal cryptococcosis in a cat. The strain grew extremely slowly at 35°C and failed to grow at 37°C in vitro. Histopathological sections of the infected tissue revealed yeast cells producing hyphae up to several hundred micrometers in length, in addition to numerous encapsulated yeast cells typical of C. neoformans. The cultures grown on yeast extract-peptone-glucose agar at 35°C also produced some yeast cells with germ tube-like hyphal elements up to 100 µm in length.

* Corresponding author. Mailing address: Department of Comparative Medicine, College of Veterinary Medicine, University of Tennessee, 2407 River Dr., Knoxville, TN 37996. Phone: (865) 974-5715. Fax: (865) 974-5640. E-mail: bemis{at}utk.edu.

dagger Present address: Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute, Blacksburg, VA 24061.

Journal of Clinical Microbiology, February 2000, p. 926-928, Vol. 38, No. 2
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Chung, S., Mondon, P., Chang, Y. C., Kwon-Chung, K. J. (2003). Cryptococcus neoformans with a Mutation in the Tetratricopeptide Repeat-Containing Gene, CCN1, Causes Subcutaneous Lesions but Fails To Cause Systemic Infection. Infect. Immun. 71: 1988-1994 [Abstract] [Full Text]  
  • Steen, B. R., Lian, T., Zuyderduyn, S., MacDonald, W. K., Marra, M., Jones, S. J.M., Kronstad, J. W. (2002). Temperature-Regulated Transcription in the Pathogenic Fungus Cryptococcus neoformans. Genome Res 12: 1386-1400 [Abstract] [Full Text]  
  • Wang, P., Nichols, C. B., Lengeler, K. B., Cardenas, M. E., Cox, G. M., Perfect, J. R., Heitman, J. (2002). Mating-Type-Specific and Nonspecific PAK Kinases Play Shared and Divergent Roles in Cryptococcus neoformans. Eukaryot Cell 1: 257-272 [Abstract] [Full Text]  


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