This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bornet, C.
Right arrow Articles by Bollet, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bornet, C.
Right arrow Articles by Bollet, C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, March 2000, p. 1048-1052, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Imipenem Resistance of Enterobacter aerogenes Mediated by Outer Membrane Permeability

Charléric Bornet,* Anne Davin-Regli, Claude Bosi, Jean-Marie Pages, and Claude Bollet

Enveloppe Bactérienne, Antibiotiques et Colonisation, CJF 96-06 INSERM, Faculté de Médecine, Université de la Mediterrannée, 13385 Marseille Cedex 05, France

Received 28 June 1999/Returned for modification 22 August 1999/Accepted 11 December 1999

Multidrug-resistant Enterobacter aerogenes strains are increasingly isolated in Europe and especially in France. Treatment leads to imipenem resistance, because of a lack of porin. We studied the evolution of resistance in 29 strains isolated from four patients during their clinical course. These strains belonged to the prevalent epidemiological type observed in France in previous studies (C. Bosi, et al., J. Clin. Microbiol. 37:2165-2169, 1999; A. Davin-Regli et al., J. Clin. Microbiol. 34:1474-1480, 1996). They also harbored a TEM-24 extended-spectrum beta -lactamase-coding gene. Thirteen strains were susceptible to gentamicin and resistant to imipenem and cefepime. All of the patients showed E. aerogenes strains with this resistance after an imipenem treatment. One patient showed resistance to imipenem after a treatment with cefpirome. Twelve of these 13 strains showed a lack of porin. Cessation of treatment with imipenem for three patients was followed by reversion of susceptibility to this antibiotic and the reappearance of porins, except in one case. For one patient, we observed three times in the same day the coexistence of resistant strains lacking porin and susceptible strains possessing porin. The emergence of multidrug-resistant E. aerogenes strains is very disquieting. In our study, infection by E. aerogenes increased the severity of the patients' illnesses, causing a 100% fatality rate.

* Corresponding author. Mailing address: CJF 96-06 INSERM, Faculté de Médecine, 27 Bd. Jean Moulin, 13385 Marseille Cedex 05, France. Phone: (33) 4 91 32 45 29. Fax: (33) 4 91 32 46 06. E-mail: cbollet{at}ap-hm.fr.

Journal of Clinical Microbiology, March 2000, p. 1048-1052, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Doumith, M., Ellington, M. J., Livermore, D. M., Woodford, N. (2009). Molecular mechanisms disrupting porin expression in ertapenem-resistant Klebsiella and Enterobacter spp. clinical isolates from the UK. J Antimicrob Chemother 63: 659-667 [Abstract] [Full Text]  
  • Kaczmarek, F. M., Dib-Hajj, F., Shang, W., Gootz, T. D. (2006). High-Level Carbapenem Resistance in a Klebsiella pneumoniae Clinical Isolate Is Due to the Combination of blaACT-1 {beta}-Lactamase Production, Porin OmpK35/36 Insertional Inactivation, and Down-Regulation of the Phosphate Transport Porin PhoE.. Antimicrob. Agents Chemother. 50: 3396-3406 [Abstract] [Full Text]  
  • Mena, A., Plasencia, V., Garcia, L., Hidalgo, O., Ayestaran, J. I., Alberti, S., Borrell, N., Perez, J. L., Oliver, A. (2006). Characterization of a Large Outbreak by CTX-M-1-Producing Klebsiella pneumoniae and Mechanisms Leading to In Vivo Carbapenem Resistance Development.. J. Clin. Microbiol. 44: 2831-2837 [Abstract] [Full Text]  
  • Walther-Rasmussen, J., Hoiby, N. (2006). OXA-type carbapenemases. J Antimicrob Chemother 57: 373-383 [Abstract] [Full Text]  
  • Thiolas, A., Bollet, C., La Scola, B., Raoult, D., Pages, J.-M. (2005). Successive Emergence of Enterobacter aerogenes Strains Resistant to Imipenem and Colistin in a Patient. Antimicrob. Agents Chemother. 49: 1354-1358 [Abstract] [Full Text]  
  • Bratu, S., Landman, D., Alam, M., Tolentino, E., Quale, J. (2005). Detection of KPC Carbapenem-Hydrolyzing Enzymes in Enterobacter spp. from Brooklyn, New York. Antimicrob. Agents Chemother. 49: 776-778 [Abstract] [Full Text]  
  • Chollet, R., Chevalier, J., Bollet, C., Pages, J.-M., Davin-Regli, A. (2004). RamA Is an Alternate Activator of the Multidrug Resistance Cascade in Enterobacter aerogenes. Antimicrob. Agents Chemother. 48: 2518-2523 [Abstract] [Full Text]  
  • Chevalier, J., Bredin, J., Mahamoud, A., Mallea, M., Barbe, J., Pages, J.-M. (2004). Inhibitors of Antibiotic Efflux in Resistant Enterobacter aerogenes and Klebsiella pneumoniae Strains. Antimicrob. Agents Chemother. 48: 1043-1046 [Abstract] [Full Text]  
  • Gayet, S., Chollet, R., Molle, G., Pages, J.-M., Chevalier, J. (2003). Modification of Outer Membrane Protein Profile and Evidence Suggesting an Active Drug Pump in Enterobacter aerogenes Clinical Strains. Antimicrob. Agents Chemother. 47: 1555-1559 [Abstract] [Full Text]  
  • Yigit, H., Anderson, G. J., Biddle, J. W., Steward, C. D., Rasheed, J. K., Valera, L. L., McGowan, J. E. Jr., Tenover, F. C. (2002). Carbapenem Resistance in a Clinical Isolate of Enterobacter aerogenes Is Associated with Decreased Expression of OmpF and OmpC Porin Analogs. Antimicrob. Agents Chemother. 46: 3817-3822 [Abstract] [Full Text]  
  • Chollet, R., Bollet, C., Chevalier, J., Mallea, M., Pages, J.-M., Davin-Regli, A. (2002). mar Operon Involved in Multidrug Resistance of Enterobacter aerogenes. Antimicrob. Agents Chemother. 46: 1093-1097 [Abstract] [Full Text]  
  • Livermore, D. M., Carter, M. W., Bagel, S., Wiedemann, B., Baquero, F., Loza, E., Endtz, H. P., van den Braak, N., Fernandes, C. J., Fernandes, L., Frimodt-Moller, N., Rasmussen, L. S., Giamarellou, H., Giamarellos-Bourboulis, E., Jarlier, V., Nguyen, J., Nord, C.-E., Struelens, M. J., Nonhoff, C., Turnidge, J., Bell, J., Zbinden, R., Pfister, S., Mixson, L., Shungu, D. L. (2001). In Vitro Activities of Ertapenem (MK-0826) against Recent Clinical Bacteria Collected in Europe and Australia. Antimicrob. Agents Chemother. 45: 1860-1867 [Abstract] [Full Text]  
  • Mammeri, H., Laurans, G., Eveillard, M., Castelain, S., Eb, F. (2001). Coexistence of SHV-4- and TEM-24-Producing Enterobacter aerogenes Strains before a Large Outbreak of TEM-24-Producing Strains in a French Hospital. J. Clin. Microbiol. 39: 2184-2190 [Abstract] [Full Text]  
  • De Gheldre, Y., Struelens, M. J., Glupczynski, Y., De Mol, P., Maes, N., Nonhoff, C., Chetoui, H., Sion, C., Ronveaux, O., Vaneechoutte, M. (2001). National Epidemiologic Surveys of Enterobacter aerogenes in Belgian Hospitals from 1996 to 1998. J. Clin. Microbiol. 39: 889-896 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»