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Journal of Clinical Microbiology, March 2000, p. 1276-1278, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Experimental Inoculation with Human Granulocytic Ehrlichia Agent Derived from High- and Low-Passage Cell Culture in Horses

Nicola Pusterla,1,* John E. Madigan,1 Kristin M. Asanovich,2 Joon-Seok Chae,1 Elfriede Derock,1 Christian M. Leutenegger,1 Jeannine Berger Pusterla,1 Hans Lutz,3 and J. Stephen Dumler2

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California 956161; Division of Medical Microbiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 212872; and Department of Veterinary Internal Medicine, University of Zurich, CH-8057 Zurich, Switzerland3

Received 3 September 1999/Returned for modification 10 December 1999/Accepted 24 December 1999

We report the successful infection throughout intravenous inoculation with low and high passage of in vitro-grown human granulocytic ehrlichiosis (HGE) agent in horses. Differences in disease severity but not in incubation time, hematological changes, PCR detection, ehrlichial load, seroconversion time, and titer range were noted between horses infected with a low and a high passage of in vitro-grown HGE agent.

* Corresponding author. Mailing address: School of Veterinary Medicine, University of California, Davis, CA 95616. Phone: (530) 752-2371. Fax: (530) 752-0414. E-mail: npusterla{at}ucdavis.edu.

Journal of Clinical Microbiology, March 2000, p. 1276-1278, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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