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Journal of Clinical Microbiology, March 2000, p. 1290-1292, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Outbreak of Infections Caused by Pseudomonas aeruginosa Producing VIM-1 Carbapenemase in Greece

Athanassios Tsakris,1,* Spyros Pournaras,2 Neil Woodford,3 Marie-France I. Palepou,3 Gioia S. Babini,3 John Douboyas,2 and David M. Livermore3

Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54 006 Thessaloniki,1 and Department of Microbiology, AHEPA University Hospital, 54 636 Thessaloniki,2 Greece, and Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom3

Received 19 October 1999/Returned for modification 4 December 1999/Accepted 24 December 1999

Resistance to imipenem and meropenem was observed in 211 (16.5%) isolates of Pseudomonas aeruginosa recovered in a Greek university hospital during 1996 to 1998. In six isolates selected from throughout this period, high-level resistance to both carbapenems (MICs >=  128 µg/ml) was associated with production of the class B beta -lactamase VIM-1. blaVIM-bearing isolates belonged to serotype O:12 and were indistinguishable by pulsed-field gel electrophoresis.

* Corresponding author. Mailing address: Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54 006 Thessaloniki, Greece. Phone: 30 31 99 90 91. Fax: 30 31 99 48 21. E-mail: atsakris{at}med.auth.gr.

Journal of Clinical Microbiology, March 2000, p. 1290-1292, Vol. 38, No. 3
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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