This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Song, J.-H.
Right arrow Articles by Appelbaum, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Song, J.-H.
Right arrow Articles by Appelbaum, P. C.

 Previous Article  |  Next Article 

Journal of Clinical Microbiology, April 2000, p. 1641-1644, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Molecular Characterization of Multidrug-Resistant Streptococcus pneumoniae Isolates in Korea

Jae-Hoon Song,1,* Ji-won Yang,2 Joung Hwa Jin,3 Shin Woo Kim,1 Choon Kwan Kim,1 Hyuck Lee,1 Kyong Ran Peck,1 Sungmin Kim,1 Nam Yong Lee,4 Michael R. Jacobs,5 Peter C. Appelbaum,6 and The Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study Group3

Division of Infectious Diseases1 and Department of Clinical Pathology,4 Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute,2 and Asian-Pacific Research Foundation for Infectious Diseases,3 Seoul, Korea; Case Western Reserve University, Cleveland, Ohio5; and Hershey Medical Center, Hershey, Pennsylvania6

Received 23 September 1999/Returned for modification 1 December 1999/Accepted 10 January 2000

Pulsed-field gel electrophoresis, ribotyping, and fingerprinting analysis of 22 invasive isolates of multidrug-resistant (MDR) pneumococci from Korea showed that 59 to 82% were genetically related. DNA sequencing of the PBP 2B gene showed relatively uniform alterations in nucleotides (5.4 to 7.8%) and amino acids (3.0 to 4.3%), while Asn-276right-arrowLys, Arg-285right-arrowCys and Ser-305right-arrowPhe substitutions were unique to Korean MDR strains, suggesting the spread of a few epidemic clones of resistant pneumococci within Korea.

* Corresponding author. Mailing address: Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IL-won dong Kangnam-ku, Seoul 135-710, Korea. Phone: 82-2-3410-0320. Fax: 82-2-3410-0328. E-mail: jhsong{at}smc.samsung.co.kr.

Journal of Clinical Microbiology, April 2000, p. 1641-1644, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Pagliero, E., Chesnel, L., Hopkins, J., Croize, J., Dideberg, O., Vernet, T., Di Guilmi, A. M. (2004). Biochemical Characterization of Streptococcus pneumoniae Penicillin-Binding Protein 2b and Its Implication in {beta}-Lactam Resistance. Antimicrob. Agents Chemother. 48: 1848-1855 [Abstract] [Full Text]  
  • Baek, J. Y., Ko, K. S., Oh, W. S., Jung, S.-I., Kim, Y. S., Chang, H.-H., Lee, H., Kim, S. W., Peck, K. R., Lee, N. Y., Song, J.-H. (2004). Unique Variations of pbp2b Sequences in Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates from Korea. J. Clin. Microbiol. 42: 1746-1750 [Abstract] [Full Text]  
  • Greenberg, D., Dagan, R., Muallem, M., Porat, N. (2003). Antibiotic-Resistant Invasive Pediatric Streptococcus pneumoniae Clones in Israel. J. Clin. Microbiol. 41: 5541-5545 [Abstract] [Full Text]  
  • Parry, C. M., Duong, N. M., Zhou, J., Mai, N. T. H., Diep, T. S., Thinh, L. Q., Wain, J., Van Vinh Chau, N., Griffiths, D., Day, N. P. J., White, N. J., Hien, T. T., Spratt, B. G., Farrar, J. J. (2002). Emergence in Vietnam of Streptococcus pneumoniae Resistant to Multiple Antimicrobial Agents as a Result of Dissemination of the Multiresistant Spain23F-1 Clone. Antimicrob. Agents Chemother. 46: 3512-3517 [Abstract] [Full Text]  
  • Ip, M., Lyon, D. J., Yung, R. W. H., Tsang, L., Cheng, A. F. B. (2002). Introduction of New Clones of Penicillin-Nonsusceptible Streptococcus pneumoniae in Hong Kong. J. Clin. Microbiol. 40: 1522-1525 [Abstract] [Full Text]  
  • Quale, J. M., Landman, D., Flores, C., Ravishankar, J. (2001). Comparison of Automated Ribotyping to Pulsed-Field Gel Electrophoresis for Genetic Fingerprinting of Streptococcus pneumoniae. J. Clin. Microbiol. 39: 4175-4177 [Abstract] [Full Text]  
  • McGee, L., McDougal, L., Zhou, J., Spratt, B. G., Tenover, F. C., George, R., Hakenbeck, R., Hryniewicz, W., Lefevre, J. C., Tomasz, A., Klugman, K. P. (2001). Nomenclature of Major Antimicrobial-Resistant Clones of Streptococcus pneumoniae Defined by the Pneumococcal Molecular Epidemiology Network. J. Clin. Microbiol. 39: 2565-2571 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»