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Journal of Clinical Microbiology, April 2000, p. 1648-1650, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of the Yields of Blood Cultures Using Serum or Plasma from Patients with Early Lyme Disease

Gary P. Wormser,1,* Susan Bittker,1 Denise Cooper,1 John Nowakowski,1 Robert B. Nadelman,1 and Charles Pavia1,2

Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York 10595,1 and New York College of Osteopathic Medicine Microbiology and Immunodiagnostic Laboratory of the New York Institute of Technology, Old Westbury, New York 115682

Received 5 November 1999/Returned for modification 20 December 1999/Accepted 2 February 2000

In an initial experiment, culture-grown Borrelia burgdorferi was added to freshly collected uninfected human blood. This in vitro study demonstrated that more spirochetes were distributed into the plasma than into the serum fraction. In a subsequent clinical study, B. burgdorferi was recovered from plasma cultures of approximately 50% of 42 patients with early Lyme disease associated with erythema migrans. The rate of recovery from plasma cultures was significantly greater than that from serum cultures (P < 0.001).

* Corresponding author. Mailing address: Division of Infectious Diseases, Room 209SE, Macy Pavilion, Westchester Medical Center, Valhalla, NY 10595. Phone: (914) 493-8865. Fax: (914) 493-7289. E-mail: Gary_Wormser{at}NYMC.EDU.

Journal of Clinical Microbiology, April 2000, p. 1648-1650, Vol. 38, No. 4
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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