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Journal of Clinical Microbiology, May 2000, p. 1988-1989, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Evaluation of the MB/BacT Mycobacterium Detection System for Susceptibility Testing of Mycobacterium tuberculosis

María S. Díaz-Infantes,1 María J. Ruiz-Serrano,1,* Lucía Martínez-Sánchez,1 Arturo Ortega,2 and Emilio Bouza1

Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañón,"1 and Reference Mycobacteriology Laboratory, Hospital Carlos III,2 Madrid, Spain

Received 3 September 1999/Returned for modification 19 October 1999/Accepted 6 February 2000

The MB/BacT mycobacterium detection system was evaluated for its performance in the susceptibility testing of Mycobacterium tuberculosis. Eighty-three M. tuberculosis isolates were processed. Results for all isoniazid-, rifampin- and streptomycin-susceptible, isoniazid-resistant, and rifampin-resistant M. tuberculosis isolates with the MB/BacT system agreed 100% with those obtained by the agar proportion method. The agreements between the two methods for streptomycin- and ethambutol-resistant isolates were 96.4 and 90.4%, respectively. The susceptibility test results were obtained in 7 days, on average. These data demonstrate that the MB/BacT system is an accurate, nonradiometric method for rapid susceptibility testing of M. tuberculosis.

* Corresponding author. Mailing address: Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario "Gregorio Marañón," Dr. Esquerdo 46, 28009 Madrid, Spain. Phone: 34-91-5868453. Fax: 34-91-5044906. E-mail: mjrfer{at}efd.net.

Journal of Clinical Microbiology, May 2000, p. 1988-1989, Vol. 38, No. 5
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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