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Journal of Clinical Microbiology, June 2000, p. 2292-2296, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Urogenital Chlamydia trachomatis Serovars in Men and Women with a Symptomatic or Asymptomatic Infection: an Association with Clinical Manifestations?

S. A. Morré,1 L. Rozendaal,1 I. G. M. van Valkengoed,2 A. J. P. Boeke,2 P. C. van Voorst Vader,3 J. Schirm,4 S. de Blok,5 J. A. R. van den Hoek,6 G. J. J. van Doornum,6 C. J. L. M. Meijer,1 and A. J. C. van den Brule1,*

Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit,1 and Institute for Research in Extramural Medicine,2 Vrije Universiteit, Department of Obstetrics and Gynecology, OLVG Hospital,5 and Municipal Health Service,6 Amsterdam, and STD Clinic, Department of Dermatology, University Hospital,3 and Regional Public Health Laboratory,4 Groningen, The Netherlands

Received 14 January 2000/Returned for modification 11 March 2000/Accepted 8 April 2000

To determine whether certain Chlamydia trachomatis serovars are preferentially associated with a symptomatic or an asymptomatic course of infection, C. trachomatis serovar distributions were analyzed in symptomatically and asymptomatically infected persons. Furthermore, a possible association between C. trachomatis serovars and specific clinical symptoms was investigated. C. trachomatis-positive urine specimens from 219 asymptomatically infected men and women were obtained from population-based screening programs in Amsterdam. Two hundred twenty-one C. trachomatis-positive cervical and urethral swabs from symptomatically and asymptomatically infected men and women were obtained from several hospital-based departments. Serovars were determined using PCR-based genotyping, i.e., restriction fragment length polymorphism analysis of the nested-PCR-amplified omp1 gene. The most prevalent C. trachomatis serovars, D, E, and F, showed no association with either a symptomatic or asymptomatic course of infection. The most prominent differences found were (i) the association of serovar Ga with symptoms in men (P = 0.0027), specifically, dysuria (P < 0.0001), and (ii) detection of serovar Ia more often in asymptomatically infected people (men and women) (P = 0.035). Furthermore, in women, serovar K was associated with vaginal discharge (P = 0.002) and serovar variants were found only in women (P = 0.045).

* Corresponding author. Mailing address: Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. Phone: 31-20-4440503. Fax: 31-20-4442964. E-mail: vandenbrule{at}azvu.nl.

Journal of Clinical Microbiology, June 2000, p. 2292-2296, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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