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Journal of Clinical Microbiology, June 2000, p. 2447-2449, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Comparison of Quantitations of Viral Load in Varicella and
Zoster
Hiroshi
Kimura,1,*
Shinji
Kido,2
Takao
Ozaki,2
Naoko
Tanaka,1
Yoshinori
Ito,1
Richard K.
Williams,3 and
Tsuneo
Morishima1
Department of Pediatrics, Nagoya University
School of Medicine, Nagoya,1 and
Department of Pediatrics, Showa Hospital,
Aichi,2 Japan, and Medical Virology
Section, Laboratory of Clinical Investigation, National Institute
of Allergy and Infectious Diseases, National Institutes of Health,
Bethesda, Maryland3
Received 24 September 1999/Returned for modification 4 January
2000/Accepted 20 March 2000
The pathogenesis of varicella and zoster and the effects of
antiviral treatment were investigated using real-time PCR for varicella-zoster virus (VZV) DNA in skin lesions and peripheral blood.
A higher occurrence of viremic VZV DNA was observed in varicella than
in zoster. Acyclovir treatment resulted in marked suppression of
viremia in varicella.
*
Corresponding author. Mailing address: Department of
Pediatrics, Nagoya University School of Medicine, 65 Tsuruma-cho,
Showa-ku, Nagoya 466-8550, Japan. Phone: 81-52-744-2303. Fax:
81-52-744-2974. E-mail: hkimura{at}med.nagoya-u.ac.jp.
Journal of Clinical Microbiology, June 2000, p. 2447-2449, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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