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Journal of Clinical Microbiology, June 2000, p. 2447-2449, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Comparison of Quantitations of Viral Load in Varicella and Zoster

Hiroshi Kimura,1,* Shinji Kido,2 Takao Ozaki,2 Naoko Tanaka,1 Yoshinori Ito,1 Richard K. Williams,3 and Tsuneo Morishima1

Department of Pediatrics, Nagoya University School of Medicine, Nagoya,1 and Department of Pediatrics, Showa Hospital, Aichi,2 Japan, and Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland3

Received 24 September 1999/Returned for modification 4 January 2000/Accepted 20 March 2000

The pathogenesis of varicella and zoster and the effects of antiviral treatment were investigated using real-time PCR for varicella-zoster virus (VZV) DNA in skin lesions and peripheral blood. A higher occurrence of viremic VZV DNA was observed in varicella than in zoster. Acyclovir treatment resulted in marked suppression of viremia in varicella.


* Corresponding author. Mailing address: Department of Pediatrics, Nagoya University School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan. Phone: 81-52-744-2303. Fax: 81-52-744-2974. E-mail: hkimura{at}med.nagoya-u.ac.jp.


Journal of Clinical Microbiology, June 2000, p. 2447-2449, Vol. 38, No. 6
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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