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Journal of Clinical Microbiology, September 2000, p. 3450-3452, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Hepatitis C Virus Core Mutations Reduce the Sensitivity of a Fluorescence Enzyme Immunoassay

Hajime Tokita,1,* Gilbert R. Kaufmann,2 Mamoru Matsubayashi,3 Isao Okuda,3 Tsukasa Tanaka,3 Hideharu Harada,1 Motokazu Mukaide,4 Kazuo Suzuki,5 and David A. Cooper2,5

Department of Gastroenterology1 and Clinical Laboratory,3 National Tokyo Hospital, Kiyose-Shi, Tokyo 204-0023, and Center for Molecular Biology and Cytogenetics, SRL, Inc., Hino-Shi, Tokyo 191-0002,4 Japan, and National Centre in HIV Epidemiology and Clinical Research, University of New South Wales,2 and Centre for Immunology, St. Vincent's Hospital,5 Sydney, New South Wales 2010, Australia

Received 28 February 2000/Returned for modification 12 May 2000/Accepted 12 June 2000

Four of 107 samples obtained from hepatitis C virus (HCV) carriers showed lower HCV core antigen levels in a fluorescence enzyme immunoassay (FEIA) than expected from corresponding HCV RNA levels. Nucleotide sequencing revealed a mutation in the HCV core region (Thr49Pro) that appears to have reduced the FEIA sensitivity.

* Corresponding author. Mailing address: Department of Gastroenterology, National Tokyo Hospital, 3-1-1 Takeoka, Kiyose-Shi, Tokyo 204-0023, Japan. Phone: 81 424 91 2111. Fax: 81 424 94 2168.

Journal of Clinical Microbiology, September 2000, p. 3450-3452, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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