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Journal of Clinical Microbiology, September 2000, p. 3463-3466, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Analysis of Genetic Heterogeneity in Chlamydia trachomatis Clinical Isolates of Serovars D, E, and F by Amplified Fragment Length Polymorphism

Servaas A. Morré,1 Jacobus M. Ossewaarde,2 Paul H. M. Savelkoul,3 Jeroen Stoof,3 Chris J. L. M. Meijer,1 and Adriaan J. C. van den Brule1,*

Department of Pathology, Section of Molecular Pathology,1 Department of Medical Microbiology and Infection Control,3 University Hospital Vrije Universiteit, Amsterdam, and Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven,2 The Netherlands

Received 12 January 2000/Returned for modification 2 May 2000/Accepted 22 June 2000

Amplified fragment length polymorphism (AFLP) fingerprinting of clinical isolates of Chlamydia trachomatis serovars D, E, and F showed a low percentage of genetic heterogeneity, but clear differences were found. Isolates from index patients and partners had identical AFLP patterns and AFLP markers. Characterization of these AFLP markers could give more insight into the differences in virulence and clinical course of C. trachomatis infections.

* Corresponding author. Mailing address: Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. Phone: 31-20-4440503/44023. Fax: 31-20-4442964. E-mail: vandenbrule{at}azvu.nl.

Journal of Clinical Microbiology, September 2000, p. 3463-3466, Vol. 38, No. 9
0095-1137/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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