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Journal of Clinical Microbiology, January 2001, p. 367-369, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.367-369.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Use of Penicillin MICs To Predict In Vitro Activity of Other beta -Lactam Antimicrobial Agents against Streptococcus pneumoniae

A. B. Brueggemann, M. A. Pfaller, and G. V. Doern*

Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242

Received 12 June 2000/Returned for modification 31 August 2000/Accepted 28 October 2000

Linear regression analysis was used to compare penicillin MICs determined with 3,129 recent clinical isolates of Streptococcus pneumoniae to MICs obtained with nine other beta-lactam antimicrobial agents. A strong correlation between penicillin MICs and those obtained with other beta-lactams was demonstrated. It may be possible to test penicillin and use MICs obtained with penicillin to predict MICs of other beta-lactam antimicrobials for Streptococcus pneumoniae.

* Corresponding author. Mailing address: Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 356-8616. Fax: (319) 356-4916. E-mail: gary-doern{at}uiowa.edu.

Journal of Clinical Microbiology, January 2001, p. 367-369, Vol. 39, No. 1
0095-1137/01/$04.00+0   DOI: 10.1128/JCM.39.1.367-369.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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